Introduction: Ethyl pyruvate (EP), a natural flavoring and fragrance agent, has been shown to exert anti-inflammatory and antioxidant actions. We tested the potential beneficial effects of EP in a rat model of acute necrotizing pancreatitis (ANP), a serious condition with a significant inflammatory explosion and oxidative stress. Material and methods: Fifty-two adult male Sprague-Dawley rats we...

The pharmacological properties and subtypes of prostanoid receptors involved in the prejunctional modulation of [(3)H]norepinephrine release from sympathetic neurons were studied using isolated rabbit aorta. Rings preincubated with [(3)H]norepinephrine were washed with physiological salt solution that contained cocaine plus corticosterone, uptake(1) and uptake(2) inhibitors, respectively, and r...

We studied the effect on both platelet aggregation and blood coagulation, known to be major risk factors in thrombogenesis, of proteins from hen egg yolk (EP). EP potently inhibited collagen-induced human platelet aggregation in a dose-dependent manner. Furthermore, EP has a synergistic effect on the inhibition of human platelet aggregation with both molsidomine, an inhibitor of cGMP-specific p...

Neonate ruminants possess little cell-wall and starch degrading enzyme activity. Importantly, early establishment of fibrolytic, amylolytic, and proteolytic capacities is influential for the early expansion of the reticulorumen epithelia. Such an early development in reticulorumen fermentation will enable a timely hepatic adaptation to volatile fatty acids assimilation. The early nutrient relea...

Using the NELS:88 database, we examined (a) the relation betweenschool size and extracurricular participation (EP) in high school, (b) the effect ofEP on 12th-grade academic achievement and self-esteem, and (c) the indirect effect of school size on achievement and self-esteem through its effect on EP. Consistent with the seminal study by Barker and Gump et al. (1964), we found higher EP among s...

Lately, the effect of quercetin supplementation (QS) on endurance performance (EP) and maximal oxygen consumption (VO2max) has been receiving much scientific and media attention. Therefore, a meta-analysis was performed to determine QS's ergogenic value on these variables. Studies were located with database searches (PubMed and SPORTDiscus) and cross-referencing. Outcomes represent mean percent...

Background: Gestational trophoblastic neoplasia (GTN) originates from placental trophoblast and is a highly chemosensitive and curable gynecologic malignancy. The present study was conducted to evaluate the effectiveness and safety of EMA/EP (etoposide, methotrexate, actinomycin-D, etoposide, and cisplatin) regimen in the treatment of high-risk GTN as well as patients’ outcome.  &nb...

Inclusive production of D(2010) mesons in deep inelastic scattering has been measured using ep and ep data obtained with the ZEUS detector at HERA using integrated luminosities of 16.7 and 65.2pb, respectively. The decay channel D → Dπ with D → Kπ and corresponding antiparticle decays were used to identify D mesons. The D cross sections in ep and ep interactions agree with NLO QCD predictions, ...

The present study was designed to investigate the central nervous system activity of 23 novel phenylpiperazine pyrrolidin-2-one derivatives. These compounds had marked antiarrhythmic and hypotensive activities and revealed affinity for α1- and α2-adrenoceptors. These effects may be related to their α-adrenolytic properties. We assessed their antidepressant-like effect in the forced swimming tes...

RATIONALE Evidence regarding exercise capacity and physical activity in children born extremely preterm (EP) is limited. Since survivors remain at high risk for developing bronchopulmonary dysplasia (BPD) and long-term pulmonary sequelae, reductions in exercise capacity and activity levels may be present. OBJECTIVES To compare maximal exercise ventilation characteristics and physical activity...