We present a study of disordered jammed hard-sphere packings in four-, five-, and six-dimensional Euclidean spaces. Using a collision-driven packing generation algorithm, we obtain the first estimates for the packing fractions of the maximally random jammed (MRJ) states for space dimensions d=4, 5, and 6 to be phi(MRJ) approximately 0.46, 0.31, and 0.20, respectively. To a good approximation, t...

Disorazoles comprise a family of 29 macrocyclic polyketides isolated from the fermentation broth of the myxobacterium Sorangium cellulosum. The major fermentation product, disorazole A1, was found previously to irreversibly bind to tubulin and to have potent cytotoxic activity against tumor cells, possibly because of its highly electrophilic epoxide moiety. To test this hypothesis, we synthesiz...

Considering the therapeutic values of bioflavonoids in colon cancer treatment, six 2'-hydroxy chalcones (C1-C6) were synthesized, characterized and screened for in vitro cytotoxicity on human colon carcinoma (HCT116) and African green monkey kidney epithelial cells (Vero). Only C5 showed selective cytotoxicity against HCT116 cells. Other potent cytotoxic compounds were C1, C2 and C3. Further sc...

This note investigates πT,c1,c2(a1,a2)=P(supt∈[0,T](σ1B(t)−c1t)>a1,supt∈[0,T](σ2B(t)−c2t)>a2), where {B(t):t≥0} is a standard Brownian motion, with T>0,σ1,σ2>0,c1,c2∈R. We derive explicit formula for the probability πT,c1,c2(a1,a2) and find its asymptotic behavior both in so called many-source high-threshold regimes.

Early endothelial progenitor cells (early EPC) and late EPC are involved in endothelial repair and can rescue damaged endothelial cells by transferring organelles through tunneling nanotubes (TNT). In rodents, EPC mobilization from the bone marrow depends on sympathetic nervous system activity. Indirect evidence suggests a relation between autonomic derangements and human EPC mobilization. We a...

A self-powered autonomous RFID device with sensing and computing capabilities is presented in this paper. Powered by an RF energy-harvesting circuit enhanced by a DCDC voltage booster in silicon-on-insulator (SOI) technology, the device relies on a microcontroller and a new generation ICRFID chip to wirelessly deliver sensor data to standard RFID EPC Class-1 Generation-2 (Gen2) readers. When th...

Low complexity and efficient algorithms for Radio-Frequency Identification (RFID) are crucial to foster low-cost and energy-saving solutions. With the aim of lowering the complexity of the radio circuitry, and inspired by the superposition codes concept, we propose a novel encoding algorithm for tag-to-reader communication channels of modern RFID systems. We show that the developed scheme—despi...

Medication-related osteonecrosis of the jaw (MRONJ) is a challenging affection, considering absence “Gold Standard” treatment. Cell therapy and tissue engineering, using adipose-tissue stromal vascular fraction (SVF) containing mesenchymal cells (MSC) endothelial progenitor (EPC); scaffold with healing properties, l-platelet-rich fibrin (L-PRF), could be therapeutic option. Two cases MRONJ were...

Bone marrow (BM)-derived endothelial progenitor cells (EPC) have therapeutic potentials in promoting tissue regeneration, but how these cells are modulated in vivo has been elusive. Here, we report that RBP-J, the critical transcription factor mediating Notch signaling, modulates EPC through CXCR4. In a mouse partial hepatectomy (PHx) model, RBP-J deficient EPC showed attenuated capacities of h...