PURPOSE OF REVIEW Hyperosmolarity is a central mechanism causing ocular surface inflammation and eye irritation in typical patients suffering from tear dysfunction. Tear composition in dry eyes, or dysfunctional tear syndrome, may destabilize the tear film and cause ocular surface epithelial disease. Increased activity of matrix metalloproteinases (MMPs), especially MMP-9, plays a critical role...

AIM To investigate by electron microscopy the plane of separation of the epithelial sheet from its substratum in the procedure of alcohol delamination (ALD) in patients with recurrent corneal erosion syndrome. METHODS Ten cases of recurrent corneal erosions (RCE) secondary to trauma and seven cases related to map-dot-fingerprint dystrophy (MDFP) were treated with ALD. The epithelial sheets ob...

OBJECTIVE To describe the epithelial healing rates observed in freshly cultured rabbit corneas chemically burned with high-concentration hydrochloric acid (HCl) and sodium hydroxide (NaOH) and subsequently treated with phototherapeutic keratectomy (PTK). METHODS We obtained 126 fresh corneoscleral rims from cadaveric New Zealand white rabbits. Each cornea was exposed to 4-mm cellulose sponges...

PURPOSE To evaluate the results of sutureless amniotic membrane (AM) transplantation using fibrin glue for reconstructing corneal surfaces with partial limbal stem cell deficiency (LSCD). DESIGN Retrospective noncomparative interventional case series. METHODS Eleven eyes of nine patients that had LSCD with 120 degrees to almost 360 degrees of limbal involvement underwent superficial keratec...

We have used the fluorescent dye dichlorotriazinyl aminofluorescein (DTAF) to demonstrate corneal remodeling following keratectomy in the rabbit. The dye was applied to the surface of 3.5 mm diameter anterior keratectomy wounds produced by either lamellar dissection or photoablation with an excimer laser (193 nm) to a depth of 15, 50 or 75 microns. Stromal wounds that had been ablated in 12 con...

OBJECTIVES To compare epithelial healing time following laser epithelial keratomileusis (LASEK) and photorefractive keratectomy (PRK) with anterior segment optic coherence tomography (AS-OCT). METHODS This prospective interventional case series study comprised 56 eyes of 28 patients that underwent laser refractive surgery in the Department of Ophthalmology, Medipol University Medical Faculty,...

Abstract Purpose To compare early clinical outcomes of single-step transepithelial photorefractive keratectomy (tPRK) and (PRK) regarding refractive outcome, visual acuity, wound healing, pain intensity recovery time.d. Methods In this prospective observational study 200 eyes 100 consecutive patients with mild to moderate myopia or without astigmatism were included. One hundred each either trea...