نتایج جستجو برای: epothilone a
تعداد نتایج: 13431870 فیلتر نتایج به سال:
Peloruside A is a novel secondary metabolite isolated from a New Zealand marine sponge, Mycale hentscheli, that has potent paclitaxel-like microtubule-stabilizing activity and is cytotoxic at nanomolar concentrations. Its 16-membered macrolide ring is similar to that of epothilone, a drug currently under clinical investigation as an anticancer agent. Like paclitaxel, peloruside A arrests cells ...
Laulimalide is a cytotoxic natural product that stabilizes microtubules. The compound enhances tubulin assembly, and laulimalide is quantitatively comparable to paclitaxel in its effects on the reaction. Laulimalide is also active in P-glycoprotein overexpressing cells, while isolaulimalide, a congener without the drug's epoxide moiety, was reported to have negligible cytotoxic and biochemical ...
4.1. Aeruginosin 298-A 2002 4.2. Bleomycin 2003 4.3. Clavulones 2004 4.4. Curacin A 2005 4.5. Dysidiolide 2006 4.6. Epothilone 2006 4.7. Erythromycin A 2007 4.8. Estrone 2008 4.9. Fellutamide 2009 4.10. Fumiquinazoline 2010 4.11. Gougerotin 2010 4.12. Homocamptothecin 2010 4.13. Illudin 2011 4.14. Macrosphelide 2012 4.15. Mappicine 2012 4.16. Mniopetals and Marasmanes 2013 4.17. Murisolin 2014 ...
(+)-Discodermolide (1), a polyhydroxylated lactone isolated from the marine sponge Discodermia dissoluta,1 is currently a high-profile substance for its promise as an immunosuppressive agent1,2 and an anti-cancer drug. The compound induces apoptosis in human breast cancer cells,3 inhibits the in vitro proliferation of murine P388 leukemia cells,1 and combines synergistically with Taxol to suppr...
Numerous studies have implicated mutations in tubulin or the overexpression of specific tubulin genes in resistance to microtubule-targeted drugs. Much less is known about the role of accessory proteins that modulate microtubule behavior in the genesis of drug resistance. Here, we examine mitotic centromere-associated kinesin (MCAK), a member of the kinesin family of microtubule motor proteins ...
Abstract Aziridines derived from bioactive molecules may have unique pharmacological activities, making them used in pharmacology (e.g. mitomycin C). Furthermore, the substitution of epoxide moiety epothilone B with aziridine, an analogue epoxides, yielded a pronounced enhancement its anticancer efficacy. Thus, there is interest developing novel synthetic technologies to produce aziridines mole...
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