Venezuelan equine encephalitis virus (VEE) produces an acute infection in humans and induces a well-characterized cytopathic effect in neurons of the central nervous system (CNS). However, little is known about the role of glial cells in response to VEE infection of the CNS. Our results demonstrate that VEE is capable of a productive infection in primary astrocyte cultures and that this infecti...

Endocytic trafficking is a critical mechanism for cells to decode complex signaling pathways, including those activated by G-protein-coupled receptors (GPCRs). Heterogeneity in the endosomal network enables GPCR activity to be spatially restricted between early endosomes (EEs) and the recently discovered endosomal compartment, the very early endosome (VEE). However, the molecular machinery driv...

Venezuelan equine encephalitis virus (VEEV) is an emerging pathogen of equids and humans, but infection of its rodent reservoir hosts has received little study. To determine whether responses to infection vary among geographic populations, we inoculated 3 populations of cotton rats with 2 enzootic VEEV strains (Co97-0054 [enzootic ID subtype] and 68U201 [enzootic IE subtype]). The 3 populations...

The notion of (∈,∈ ∨q)-interval-valued fuzzy prime ideals in commutative BCK-algebras is introduced. Some characterization theorems in (∈,∈ ∨q)-interval-valued fuzzy prime ideals in commutative BCK-algebras are derived. Also we study relation between (∈,∈ ∨q)-interval-valued fuzzy prime ideal and (∈ ∨q)-interval-valued fuzzy level prime ideals. Characterization of interval-valued fuzzy set to b...

Venezuelan equine encephalitis (VEE) is reemerging in Peru. VEE virus subtype ID in Peru has not been previously associated with severe disease manifestations. In 2006, VEE virus subtype ID was isolated from a boy with severe febrile disease and gastrointestinal bleeding; the strain contained 2 mutations within the PE2 region.

One of the most important questions in arbovirology concerns the origin of epidemic Venezuelan equine encephalitis (VEE) viruses; these viruses caused periodic, extensive epidemics/epizootics in the Americas from 1938-1973 (reaching the United States in 1971) but had recently been presumed extinct. We have documented the 1992 emergence of a new epidemic/epizootic VEE virus in Venezuela. Phyloge...

An epitope-blocking enzyme-linked immunosorbent assay was developed for the rapid differentiation of serologic responses to enzootic variety IE and ID versus epizootic variety IAB and IC strains of Venezuelan equine encephalitis (VEE) virus. Two monoclonal antibodies that differentially recognize epizootic versus enzootic VEE virus epitopes were used to measure the serotype-specific blocking ab...

Traditional spatial queries return, for a given query object q, all database objects that satisfy a given predicate, such as epsilon range and k-nearest neighbors. This paper defines and studies inverse spatial queries, which, given a subset of database objects Q and a query predicate, return all objects which, if used as query objects with the predicate, contain Q in their result. We first sho...

Qualitative thematic maps are graphic representations of the process of areal differentiation, a process recognized as one of the hallmarks of the geographer’s craft and one of geography’s grand traditions. Traditionally the process can best be described as classification based on Boolean Set Theory wherein the area bounded by the cartographic line is considered to be in that class for the targ...

In this note we deal with intuitionistic modal logics over $\mathcal{M}\mathcal{I}PC$ and predicate superintuitionistic logics. We study the correspondence between the lattice of all (normal) extensions of MTPC and the lattice of all predicate superintuitionistic logics. Let $\mathrm{L}_{Prop}$ denote a propositional language which contains two modal operators $\square$ and $\mathrm{O}$ , and $...