The pharmacological properties of a novel selective 5-hydroxytryptamine1A (5-HT1A) receptor antagonist, NAD-299 [(R)-3-N,N-dicyclobutylamino-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrogen (2R,3R)-tartrate monohydrate] were examined in vitro and in vivo and compared with the reference 5-HT1A receptor antagonist, WAY-100635 [N-(2-(1-(4-(2-methoxyphenyl)piperazin-yl))ethyl)-N-(2-pyrid...

As part of an ongoing program started at the Canada{France{Hawaii Telescope, we have observed Arp 299 and NGC 7469 in broad and narrow bands with PUEO, the facility adaptive optics system. Locating precisely the regions where starburst activity occurs can help to understand the events that may have led to enhanced star formation. Previous results Rouan, 1998a], Lai etal, 1998a] have shown that ...

Snapper, James R., Weixuan Lu, Peter L. Lefferts, and John S. Thabes. Effect of platelet-activating factorreceptor antagonism on endotoxin-induced lung dysfunction in sheep. J. Appl. Physiol. 84(5): 1610–1614, 1998.—To further define the role of platelet-activating factor (PAF) in endotoxin-induced lung dysfunction, we examined the effect of ABT-299, a specific and potent PAF-receptor antagonis...

Actinic keratosis (AK) and squamous cell carcinomain situ (SCCIS) are the most common precancerous lesions may progress to cutaneous carcinoma (cSCC), second cancer in US. Biomarker identification associated with keratinocyte clones undergoing UV-induced selection provide new targets treat AK/SCCIS. Prior studies using comparative whole exome-seq RNA-seq of SCCIS epidermis identified UV-signatu...

PURPOSE Oct4 was reported to be one of the most important pluripotency transcription factors in the biology of stem cells including cancer stem cells, and progressed malignant cells. Here we report the investigation of gene expression control of Oct4 by selected human microRNAs and the physiological effect of Oct4 silencing in invasive cancer cells. METHODS AND RESULTS High throughput lucifer...