Soybean isoflavones have structural similarity to estrogen and have attracted much attention due to their prevention of postmenopausal symptoms. It is critical for women to maintain a high bone mineral density (BMD) prior to menopause to prevent osteoporosis. In the present study, the effect of isoflavone aglycone (IA) supplementation on bone turnover was examined in relation to the estrogen re...

The knowledge regarding the intestinal microbial types involved in isoflavone bioavailability and metabolism is still limited. The present work reports the influence of a treatment with isoflavones for 6 months on the fecal bacterial communities of 16 menopausal women, as determined by culturing and culture-independent microbial techniques. Changes in fecal communities were analyzed with respec...

Circulating hormones are associated with mammographic density, an intermediate marker of breast cancer risk. Differences in circulating hormones, including estrone and testosterone, have been observed in premenopausal women based on their capacity to metabolize daidzein, an isoflavone found predominantly in soybeans. Equol and O-desmethylangolensin (O-DMA) are products of intestinal bacterial m...

Equol, one of the intestinal microflora metabolites of daidzein, has gained much attention for having greater bioactivity than its precursor (daidzein and daidzin) and seeming to be promoted by hydrogen gas. The effects of lactulose on the equol-producing capacity and liver antioxidant status of barrows treated with daidzein were investigated in this study. Male castrated piglets (barrows) of L...

Lower CVD incidence is reported in Asian populations consuming soya-containing food. As polymorphonuclear leukocytes (PMN) are involved in the risk of CVD, we investigated the modulatory effect of soya isoflavones on several PMN functions and their molecular mechanisms in vitro. PMN, isolated from blood from healthy subjects, were tested upon activation with 1 microm- n-formyl-methyl-leucyl-phe...

I The phyto-estrogens formononet in (7-hydroxy-4 methoxylsoflavone) and biochanin A (5-7-dlhydroxy-4-methoxylsof lavone) were independently incubated in vitro at 39~ in bovine rumen fluid from a fistulated steer receiving an alfalfa hay diet. Formononet in was incubated in studies 1 and 2, whereas biochanin A was incubated in s tudy 3. The isoflavones were separated and quantified by high perfo...

Adlercreutzia equolifaciens DSM 19450(T) was isolated from human feces and is able to metabolize daidzeins (soybean isoflavonoids) to equol. Here, we report the finished and annotated genome sequence of this organism.

OBJECTIVES This paper reported the effects of commonly used whole soy foods (soy flour) and purified daidzein (one of the major isoflavones and the precursor of equol) on changes in anthropometric measurements and body composition in a 6-month double-blind, randomized, placebo-controlled trial among prehypertensive postmenopausal women who are also equol producers. METHODS 270 eligible women ...