In evolution of mammals, some of essential genes for placental development are known to be of retroviral origin, as syncytin-1 derived from an envelope (env) gene of an endogenous retrovirus (ERV) aids in the cell fusion of placenta in humans. Although the placenta serves the same function in all placental mammals, env-derived genes responsible for trophoblast cell fusion and maternal immune to...

Envelope (env) proteins of certain endogenous retroviruses (ERVs) participate in various pathophysiological processes. In this study, we characterized pathophysiologic properties of two murine leukemia virus-type ERV (MuLV-ERV) env genes cloned from the ovary of C57BL/6J mice. The two env genes (named ENV(OV1) and ENV(OV2)), with 1,926 bp coding region, originated from two MuLV-ERV loci on chro...

Abstract The objective of this study was to evaluate the impact endophyte-infected tall fescue (E+) seed, and ergovaline (ERV), on gut satiety hormones investigate changes in post-absorptive metabolism. Holstein steers (n=12; 260 ± 16 kg) were assigned one three treatments (ERV concentration diet dry matter): 0, 1.8, 2.7 ppm with animals being adapted an indoor environment for 4 days followed b...

Immunogenic cancer therapies, including radiation and hypomethylating agents, such as 5-azacytidine, rely on tumor cell-intrinsic activation of the RNA receptor RIG-I for their synergism with immune checkpoint inhibitors. Possible ligands are small nuclear (snRNA) endogenous retroviral elements (ERV) leaking from nucleus during programmed cell death.

The single core Energy Recovery Ventilator (ERV) used in this study is equipped with defrost control that recirculates the exhaust indoor air, while keeps outdoor air intake damper closed. This strategy has disadvantage of reducing supplied to house, which may affect quality. First, paper presents new correlation-based models supply temperature T 2 after energy recovery during normal and operat...

Electronic Health Record (EHR) use is expected to quickly increase in the USA. It is the hope of the federal government and many hospitals that EHR use will not only increase, but also mature from basic applications such as EHR for results viewing (ERV) to more advanced applications such as Computerized Provider Order Entry (CPOE). Today, considerable heterogeneity exists among hospitals with r...

ERV-3 is an evolutionarily conserved single-copy human endogenous retrovirus with a coding envelope gene potentially involved in important placental functions. We have investigated the sequence variability of this gene among 150 unrelated Caucasian individuals and found eight polymorphic sites. One of them corresponds to the introduction of a stop codon resulting in the production of a severely...

Viruslike particles which displayed a peculiar wheellike appearance that distinguished them from A-, B- or C-type particles had previously been described in the early mouse embryo. The maximum expression of these so-called epsilon particles was observed in two-cell-stage embryos, followed by their rapid decline at later stages of development and no particles detected at the zygote one-cell stag...