A skin lesion previously unassociated with Crohn's disease is described. Although superficially resembling erythema nodosum it runs a different clinical course and has different histological appearances, the central feature being necrobiotic collagen. The term ;nodular necrobiosis' is suggested.

The nodules were sometimes the exacerbation of existing lesions, or sometimes the eruption of fresh lesions. The nodules themselves varied from about the size of a pea to about the size of a shilling, and they were usually tender on pressure. Ankaful Leprosarium is the headquarters of the Ghana Leprosy Service and is situated 6 miles from the coast and is 1 00 miles west of Accra. It admits pri...

Sir, Severe, chronic, recurrent erythema nodosum leprosum (ENL) is a serious problem. Patients are in need of effective and safe treatment because there is a danger of steroid dependence. Thalidomide has been shown to be highly effective in the treatment of refractory ENLs.[1] A number of dosage regimens of thalidomide, an expensive drug, have been tried.[1-3] We describe our experience of the ...

I NTRODUCTION. .-kB()uT a 'ea r ago Professor'Ilornson suggested to iie that it Would be intelesting to examine the medical histories of a serieis of cases of ervtlhenia nlodosutim, to see whetherthere was in anxr of thienm anla evidence of a definitelv tuberculous or rheumatic origin. Dr. Turkington18 lhas alread\y put the tuberculous theory before the Society, andl if the pr-eseint series sho...

Vol. 27, No. 6, 2015 765 Received December 10, 2014, Revised January 14, 2015, Accepted for publication February 4, 2015 Corresponding author: Joong Sun Lee, Department of Dermatology, Eulji University Hospital, 95 Dunsanseo-ro, Seo-gu, Daejeon 35233, Korea. Tel: 82-42-611-3035, Fax: 82-42-259-1111, E-mail: sun_lee@ eulji.ac.kr This is an Open Access article distributed under the terms of the C...

One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of sid...