Asymmetric distribution of proteins and other molecules within cells leads to cell polarization. One of the most studied examples occurs in epithelial cells that polarize to form apical and basolateral surfaces (Nelson, 2003). Although we know much about directed protein trafficking after cells are polarized, less is known about the initial mechanisms that lead to polarization. Genetic and bioc...

In this issue of Neuron, Xie et al. (2013) identified protein phosphatase 4c (PP4c) as a new component in the regulation of spindle orientation during mammalian neurogenesis. Importantly, their findings uncovered a novel and critical temporal aspect of the regulation of spindle orientation during neurogenesis.

Wild areas provide a wide array of recreational opportunities in nature, including informal camping. We examined the potential for land degradation associated with campsites accessible by vehicle on margins wild country Central Plateau Tasmania, where alpine and sub-alpine ecosystems numerous glacial periglacial wetlands sit within Tasmanian Wilderness World Heritage Area. There were no integra...

Strength-based approaches that explore resilience and health among Native communities are needed. This report highlights the results from a sources of strength inventory reported over a 2-year period by participants (N = 48) from a Montana tribe who attended cultural camps. The authors found the sources of strength scale to be a reliable and valid measure for the population (N = 11 items, α = ....