OBJECTIVE To determine whether some participants in the Diabetes Prevention Program were more or less likely to benefit from metformin or a structured lifestyle modification program. DESIGN Post hoc analysis of the Diabetes Prevention Program, a randomized controlled trial. SETTING Ambulatory care patients. PARTICIPANTS 3060 people without diabetes but with evidence of impaired glucose me...

According to a recent survey, most Americans think that drivers should not drink alcohol and then drive. Nonetheless, our legal system generally relates certain offenses to the amount of alcohol detected in a driver's body. The amount of alcohol is usually referred to as BAC -blood alcohol concentration -although it is often measured in the breath where the alcohol level in the water vapor of t...

Let K〈X〉 be a free associative algebra over a field K of characteristic 0 and let each of the noncommuting polynomials f, g ∈ K〈X〉 generate its centralizer. Assume that the leading homogeneous components of f and g are algebraically dependent with degrees which do not divide each other. We give a counterexample to the recent conjecture of Jie-Tai Yu that deg([f, g]) = deg(fg − gf) > min{deg(f),...

We shall give a lower estimate of harmonic‎ ‎functions of order greater than one in a half space‎, ‎which‎ ‎generalize the result obtained by B‎. ‎Ya‎. ‎Levin in a half plane‎.

Global risk scores use individual level information on nonmodifiable risk factors (such as age, sex, ethnicity and family history) and modifiable risk factors (such as smoking status and blood pressure) to predict an individual’s absolute risk of an adverse event over a specified period of time in the future. Cardiovascular risk scores have two major uses in practice. First, they can be used to...

BACKGROUND frail older people often require tailored rehabilitation in order to remain at home, especially following a period of hospitalisation. Restorative care services aim to enhance an older person's ability to remain improve physical functioning, either at home or in residential care but evidence of their effectiveness is limited. OBJECTIVE to evaluate the effectiveness of a restorative...

BACKGROUND AND PURPOSE The integrity of white matter tracts connecting different parts of the brain is important for rapid compensation for the lost function from ischemic stroke. Impaired white matter reserve capacity secondary to leukoaraiosis may facilitate detection of new symptomatic ischemic events that would otherwise remain inconspicuous after an initial ischemic stroke. We sought to id...