Coagulation factor XI (FXI) plays an important part in both venous and arterial thrombosis, rendering FXIa a potential target for the development of antithrombotic therapy. The kunitz protease inhibitor (KPI) domain of protease nexin-2 (PN2) is a potent, highly specific inhibitor of FXIa, suggesting its possible role in the inhibition of FXI-dependent thrombosis in vivo. Therefore, we examined ...

Occlusio Supra Occlusionem: Intracranial Occlusions Following Carotid Thrombosis as Diagnosed by Cerebral Angiography • Collateral circulation between internal and external carotid arteries was sufficient to thoroughly opacify the middle cerebral artery on cerebral angiography in 11 of 100 patients with internal carotid occlusion. In four of the 11, the branches of the middle cerebral were inta...

Background: Although the prevalence of both type 1 and 2 diabetes mellitus is increasing worldwide, DM rising more rapidly, because sedentary lifestyle, obesity increased life expectancy. Objectives: To study correlation between fasting postprandial triglyceride levels Carotid artery intimal medial thickness (CIMT) in Type Diabetic Patients. Material Methods: This cross sectional observation wa...

Coagulation factor XI (FXI) plays an important part in both venous and arterial thrombosis, rendering FXIa a potential target for the development of antithrombotic therapy. The kunitz protease inhibitor (KPI) domain of protease nexin-2 (PN2) is a potent, highly specific inhibitor of FXIa, suggesting its possible role in the inhibition of FXI-dependent thrombosis in vivo. Therefore, we examined ...

Background & Aims: Diabetes is a very important factor for stroke due to blocked blood vessels. It can involve systemic and cerebrovascular arteries at the same time via microangiopathy and macroangiopathy. This project aimed to compare the intima-media thickness of carotid artery in children with diabetes type and the control group. Methods: In this case-control study, 50 children with the age...

We describe the antithrombotic effects of recombinant nematode anticoagulant peptide (rNAP5), a selective and direct factor Xa inhibitor, after a single s.c. administration in canine models of arterial and venous thrombosis. The systemic anticoagulant effects of rNAP5 were evaluated initially in conscious dogs after s.c. dosing (0.03, 0.1 and 0.3 mg/kg) that resulted in a dose-dependent increas...

Internal Carotid Artery Occlusion Diagnosed by Doppler Ultrasound • Using a transcutaneous Doppler ultrasonic blood velocity detector, retrograde ophthalmic artery blood flow was demonstrated in four patients, all of whom had angiographically confirmed occluded internal carotid arteries. In three, compression of the facial artery obliterated the ophthalmic artery signal. In a fourth patient com...

We report a case of delayed cerebral infarction due to stent longitudinal folding deformation following carotid artery stenting using a self-expandable stent with an open-cell design. The stented segment of the left common carotid artery was divided into two different lumens by this folding deformation, and the separated lumens became restricted with in-stent thrombosis. Although no established...

Two patients with untreated polycythaemia vera developed intracranial internal carotid arterial occlusion followed by monocular blindness and the characteristic features of ipsilateral cavernous sinus thrombosis. Primary septic source and signs of systemic infection were absent. It is suggested that the predisposing factors in this unusual syndrome were hyperviscosity and venous sludging induce...

Concerns about carotid artery stenting (CAS) center primarily on procedural complications like acute occlusion, stroke, and long-term intrastent restenosis. External carotid artery (ECA) thrombosis is observed during CAS follow-up, but it often remains asymptomatic or, at worst, results in jaw claudication. We report here a case of late occlusion of the ECA after CAS with symptoms of acute homo...