Ethanol-induced excitation of ventral tegmental area dopamine (DA VTA) neurons is thought to be critical for the reinforcing effects of ethanol. Although ligand-gated ion channels are known to be the targets of ethanol, ethanol modulation of voltage-dependent ion channels of central neurons has not been well studied. We have demonstrated that ethanol excites DA VTA neurons by the reduction of s...

Background: The problem of alcohol dependence, as well as the repercussion of alcohol consumption is one of the most dramatic and socially relevant problems for modern society. Aims: Studying the development of tolerance to anxiolytic, psycho stimulant and analgesic effects of ethanol upon repeated intragastric administration of ethanol in the same dose, but in various volumes. Methods: Male Wi...

Weisinger, R. S., J. R. Blair-West, P. Burns, and D. A. Denton. Intracerebroventricular infusion of angiotensin II increases water and ethanol intake in rats. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R162–R172, 1999.—The influence of prolonged ingestion of ethanol on stimulation of water or ethanol intake by intracerebroventricular infusion of ANG II was evaluated in rats...

Background: Blood alcohol concentration is a major factor in forensic analysis in criminal and civil litigation. Along with ethanol, other volatile compounds such as n-propanol are produced as products of putrefaction. The aim of this study is the evaluation of ethanol and n-propanol in postmortem blood. Methods: A case-control study was done on 300 blood samples obtained from cadavers that...

Compelling evidence has shown a pivotal role of dopaminergic function in drug addiction. Recently, the lateral habenula (LHb) has attracted a great deal of attention as another target for abused drugs in the brain because its role in regulating dopaminergic system, among others. GABA and glycine are major inhibitory neurotransmitters. Their corresponding receptors are key targets of ethanol. Th...

The electrochemical oxidation on platinum and platinum rhodium bimetallic electrodes was studied by Differential Electrochemical Mass Spectrometry for several ethanol concentrations in solution. It is found that increasing the ethanol concentration the production of the partially oxidized products (acetaldehyde) increases as the concentration increases. On the other hand, addition of 25% at. of...