نتایج جستجو برای: every week

تعداد نتایج: 344413  

Journal: :The Lancet Rheumatology 2021

Background The combination of tocilizumab plus a glucocorticoid taper is effective in maintaining clinical remission without requiring additional therapy patients with giant cell arteritis, as shown part one the Giant Cell Arteritis Actemra (GiACTA) trial. However, duration effect after discontinuation unknown. Here, we explored maintenance efficacy 1 year treatment, effectiveness retreatment r...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2004
K Vera L Djafari S Faivre J-S Guillamo K Djazouli M Osorio F Parker C Cioloca B Abdulkarim J-P Armand E Raymond

BACKGROUND Temozolomide has shown activity and limited toxicity in patients with primary brain tumors at doses of 150-200 mg/m(2)/day on days 1-5 every 4 weeks. In this study, a new alternative dose-dense regimen of temozolomide was explored in patients with recurrent brain tumors. PATIENTS AND METHODS In this study, we evaluated the safety, dose-limiting toxicity, maximum tolerated dose, rec...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Alejandro D Ricart John Sarantopoulos Emiliano Calvo Quincy S Chu Douglas Greene Faith E Nathan Michael E Petrone Anthony W Tolcher Kyriakos P Papadopoulos

PURPOSE The study aimed to assess the pharmacokinetic behavior of satraplatin under fasted and fed conditions, and its safety and preliminary antitumor activity in adults with advanced solid tumors. EXPERIMENTAL DESIGN Satraplatin was administered orally at 80 mg/m(2) once daily with prophylactic antiemetics for 5 consecutive days every 5 weeks. Patients were randomized to receive day 1 and d...

Journal: :Oncology 2002
Barry Mirtsching Veena Charu Saroj Vadhan-Raj Alan B Colowick Gregory Rossi Dianne Tomita William P McGuire

The safety and efficacy of darbepoetin alfa (Aranesp) at 3.0 microg/kg administered every 2 weeks and recombinant human erythropoietin (rHuEPO) given as 40,000 U weekly or 150 U/kg three times weekly were evaluated by pooling data from three darbepoetin alfa clinical studies. All studies enrolled anemic (hemoglobin < or = 11.0 g/dL) patients receiving multicycle chemotherapy. Open-label study d...

Journal: :American journal of nephrology 2003
Michael G Suranyi Jill S Lindberg Jesus Navarro Chester Elias Robert M Brenner Rowan Walker

BACKGROUND/AIMS Darbepoetin alfa is an erythropoiesis-stimulating protein that works via the same mechanism and has a threefold longer serum half-life than recombinant human erythropoietin (rHuEPO). The objective of this study was to evaluate extending the dosing interval of darbepoetin alfa to once every other week administration for the treatment of anemia in patients with chronic kidney dise...

Journal: :The Journal of Physiology 1972

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه پیام نور - دانشگاه پیام نور استان تهران - دانشکده تربیت بدنی علوم ورزشی 1390

this research was conducted to examine the effect of a concurrent training on rest level of leptin of plasma and some hormonal factors in non-athlete subjects. the research population included non-athlete men who didn’t participate in any organized sport activities. 30 men were chosen voluntarily among the above-mentioned population and were divided into 2 groups: experimental (15 subjects) an...

Journal: :Current Biology 2007

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