Heat-related illness is a growing concern for workers in temperate climates as rising temperatures and heatwaves put them at risk of exertional heat stroke. Monitoring biometrics that predict stroke, such core temperature, increasingly important. To monitor biometrics, wearable sensing technologies have been proposed an alternative to the ingestible telemetric pill. However, limited studies val...

BACKGROUND The common practice in the Israel defense Forces is that exertional heat related injury patients undergo a heat tolerance test 6-8 weeks post event as part of the "return to duty" process. In the case of a positive heat tolerance test the individual is classified as heat intolerant, in some cases however, the thermoregulatory recovery may be longer (several months), and therefore a s...

The most serious complication of sickle cell trait (SCT) is sudden death during exertion. SCT often remains unrecognized in the 2.5 million African Americans affected. Exertional collapse and sudden death associated with SCT is characterized by rhabdomyolysis, heat stroke, and cardiac arrhythmia. There is a 40-fold increased risk of sudden death in affected soldiers during military basic traini...

Background Mutations in RYR1 (ryanodine receptor type 1) are linked to the majority of malignant hyperthermia (MH) families (75%) and some cases of Exertional Heat Stroke. Two CACNA1S variants associated with MH have been functionally characterised. Historically, because of the large size of the RYR1 gene, MH families were screened for 31 diagnostic RYR1 variants only. Methods based on PCR and ...