نتایج جستجو برای: exhausted regulatory t cells
تعداد نتایج: 2030212 فیلتر نتایج به سال:
Background: Immune response is key in defense against basal cell carcinoma (BCC). We aim to better define the immune tumor microenvironment this cancer. Methods: CD8+ infiltrating lymphocytes (TILs) obtained from fresh BCC specimens nodular subtype (“nBCC”, n=6) versus infiltrative (“iBCC”, were subject single-cell RNA profiling. Data analyzed using iCellR. Results: TILs clustered based on gene...
Purpose: Respiratory papillomas, caused by human papillomaviruses types 6 and 11 (HPV6/11), are premalignant lesions with potential formalignant conversion. The cytokine and chemokinemicromilieu of papillomas is TH2-likewith amarked absence of IFN-g expression. To illuminatewhypatientswith recurrent respiratory papillomatosis (RRP) fail to effectively control their disease, we further investiga...
CD8 T cells expressing memory markers exist in naive mice and are thought to be of heterogeneous origin. It was recently reported that among such memory-phenotype (MP) CD8 T cells in naive mice, those expressing programmed death-1 (PD-1) had immune regulatory activity, but their origin and relationship with other regulatory CD8 T cell subsets remain unclear. In the current study, we examined de...
background: regulatory t cells (t-regs) have an important role in cancer by suppression of protective antitumor immune responses. regulatory t cells express the forkhead/winged helix transcription factor (foxp3) and ox40 molecules which have important regulatory roles in the immune system. objective: to evaluate foxp3 and ox40 transcripts in the peripheral blood mononuclear cells of women with ...
Abstract Clinical trials of systemic T cell checkpoint blockade in GBM patients showed only disappointing results. This may be attributed part to the immunosuppressive components immune tumor microenvironment (iTME). Therefore, major efforts have been undertaken describe iTME on a single level. However, human data composition different regions (contrast enhancing center versus peripheral infilt...
Regulatory T (T reg) cells are critical for preventing autoimmunity mediated by self-reactive T cells, but their role in modulating immune responses during chronic viral infection is not well defined. To address this question and to investigate a role for T reg cells in exhaustion of virus-specific CD8 T cells, we depleted T reg cells in mice chronically infected with lymphocytic choriomeningit...
Autoimmune hepatitis (AIH) is an immune-mediated liver disease currently treated by immunosuppressive medications with significant side effects. Thus, novel mechanistic treatments are greatly needed. We performed prospective deep immunophenotyping of blood immune cells in patients with acute AIH before and after corticosteroid therapy. Blood samples from 26 patients with acute AIH (United Kingd...
Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a devastating disease that confines ~65 million people worldwide to life of pain, severe exhaustion, cognitive deficits, flu-like symptoms, and postexertional malaise. We previously discovered decreased glycolysis, mitochondrial membrane potential, increased fatty acid oxidation in ME/CFS T cells. These features are commonl...
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