(1.2) but increases to 4.2 when age at onset is 13–15 years [3] . The loss of locomotor function, as measured by the Expanded Disability Status Scale, takes longer from the time of first attack in pediatricversus adult-onset MS, but pediatric patients reach disability milestones at a younger age than their adult counterparts. Comparative magnetic resonance imaging (MRI) studies have shown a hig...

In 2001, we followed up all patients from the 1991 Olmsted County Multiple Sclerosis (MS) prevalence cohort. We found that the longer the duration of MS and the lower the disability, the more likely a patient is to remain stable and not progress. This is particularly powerful for patients with benign MS with Expanded Disability Status Scale score of 2 or lower for 10 years or longer who have a ...

Aims: Active and progressive resistance training has a key role in functional recovery and quality of life in patients with MS. Therefore, this study aimed to investigate the effects of isotonic and isometric exercises on balance and ability in patients with MS. Materials & Methods: In this randomized clinical trial, 60 patients with MS admitted to MS Special Diseases Center in Yasuj during 20...

Patients with malignant multiple sclerosis (MMS) reach a significant level of disability within a short period of time (Expanded Disability Status Scale score of 6 within five years). The clinical profile and progression of the disease were analyzed in a Brazilian cohort of 293 patients. Twenty-five (8,53%) patients were found to have MMS and were compared with the remaining 268 (91,47%). Women...

background: it seems that serum vitamin d levels are one of the potential environmental factors affecting the severity of multiple sclerosis (ms). in this study, we aim to evaluate vitamin d levels in ms patients and healthy subjects and assess the relationship between vitamin d level and disability. methods: in this case-control study, 168 rapid relapsing ms patients and 168 matched healthy co...

Objective Analyze the demographics, clinical characteristics, efficacy and safety of natalizumab treatment in Brazilian patients with multiple sclerosis (MS) followed up for at least 12 months, in two tertiary MS care centers in São Paulo.Method We evaluated the effect of natalizumab treatment on annualized relapse rate and disability progression in 75 patients with MS treated with natalizumab ...

Background: The effects of interferon1b (IFN1b ) administration in multiple sclerosis (MS) patients have been confirmed, however, those in neuromyelitis optica (NMO) patients have not been shown. In this study, we assessed the effects of IFN1b treatment on disease exacerbation and disability progression in MS or NMO patients. Methods: We reviewed a series of 104 consecutive patients with relaps...

Abstract Background The role of adipokines such as leptin and adiponectin in regulating the immunity has been documented, however data concerning their consequence on multiple sclerosis (MS) Egyptian patients are deficient. aim this study is to demonstrate serum levels MS assess association with disease disability severity. A case–control including 60 subjects (30 30 age, sex body mass index-ma...

 Background: Multiple sclerosis (MS) is an inflammatory and demyelinating disease of central nervous system (CNS). The aim of the present study was to determine the type and the frequency of initial presenting symptoms in patients with MS and their relation with demographic characteristics in Babol, northern Iran. Methods: All patients of this study were recruited over a ten year period fr...

Abstract Multiple sclerosis (MS) patients with immunoglobulin gamma (IgG) oligoclonal bands (OCB) in the cerebrospinal fluid (CSF) have different genetic backgrounds and brain MRI features compared to those without. In this study, we aimed determine whether CSF-OCB status is associated long-term disability outcomes. We used Swedish MS register data on clinically definite known OCB status. Date ...