BackgroundLow vitamin D levels, tobacco use and high body mass index (BMI) have been linked to adverse disease outcomes in multiple sclerosis (MS), but their influence on long-term disability progression remains unclear. Therefore, we explored whether these modifiable lifestyle factors were associated with 10-year clinical patients MS.MethodsIn this prospective study, a cohort of 88 relapsing-r...

background: multiple sclerosis (ms) is an inflammatory and demyelinating disease of central nervous system (cns). the aim of the present study was to determine the type and the frequency of initial presenting symptoms in patients with ms and their relation with demographic characteristics in babol, northern iran. methods: all patients of this study were recruited over a ten year period from 200...

We have tested the hypothesis that restless leg syndrome (RLS) is related to quality of sleep, fatigue and clinical disability in multiple sclerosis (MS). The diagnosis of RLS used the four minimum criteria defined by the International Restless Legs Syndrome Study Group. Fatigue was assessed by the Fatigue Severity Scale (FSS >27), quality of sleep by the Pittsburgh Sleep Quality Index (PSQI >6...

Background Multiple sclerosis (MS) is characterized by a great inter-individual variability in disease course and severity. Some patients experience a rather mild course, controversially called 'benign MS' (BMS). The usefulness of this entity in clinical practice remains unclear. Methods We performed a literature search in PubMed, Web of Science and Cochrane Library databases from November 19...

Abstract Background Cognitive dysfunction is increasingly recognized in multiple sclerosis, even the early phase of disease. Multiple sclerosis patients with mild cognitive deficits may experience greater difficulties social contact and daily activities, irrespective physical handicap. This study aimed to estimate clinical predictors a sample Egyptian people MS. Results Significant worse perfor...

BACKGROUND Multiple sclerosis (MS) is the most common neurological disease among young adults in Canada, but few studies to date have measured the burden imposed by MS on Canadian society. OBJECTIVES To estimate the costs and quality of life of MS patients in Canada, while focusing on the burden of relapses and increasing disease severity. METHODS MS patients in Canada (N=241) completed a w...

OBJECTIVE To evaluate the outcomes of patients with multiple sclerosis (MS) who were treated with natalizumab in Kuwait. MATERIALS AND METHODS A retrospective study using the MS registry to identify patients who were treated with natalizumab was conducted. Patients' demographics, clinical characteristics and treatment parameters were collected at baseline and last follow-up visit. Primary out...

INTRODUCTION Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Because of limited efficacy and adverse side effects, identifying novel therapeutic and protective agents is important. The aim of this study is to examine the correlations between expanded disability status scale (EDSS) and cytokines after intervention with co-supplemented hemp se...

OBJECTIVES To assess the magnitude of the correlations between disability and composite MRI scores in patients with MS. METHODS T2- and T1-weighted MRI, magnetization transfer imaging, diffusion tensor imaging, and MRS imaging scans of the brain from 23 patients with MS were obtained. T2 lesion volume, T1 lesion volume, brain magnetization transfer ratio, average brain diffusivity (D), and br...

background: although the precise etiology of multiple sclerosis (ms) is unknown, it seems that both genetic and environmental factors are important. recent studies suggest that low serum vitamin d levels are important environmental factor in ms. the aim of this study was to compare the serum levels of vitamin d between ms patients and healthy subjects, and to determine its association with disa...