BACKGROUND Although the association between apolipoprotein E (APOE) genetic polymorphisms and multiple sclerosis (MS), has been debated, the presence of the epsilon4 allele has been associated with an aggressive disease progression. OBJECTIVES Present study aimed to investigate whether or not the APOE allele has an impact on disease progression in patients with MS. The study investigated the ...

background: there is a known inverse association between solar radiation and the prevalence of multiple sclerosis (ms). some studies have investigated the link between vitamin d and ms. the aim of this study was to investigate the possible association between serum 25(oh) vitamin d3 concentration and the severity of disease in iranian patients with ms. methods: patients with relapsing-remitting...

Prevalence rates of multiple sclerosis (MS) suggest an interrelationship between genetic and environmental factors, ranging worldwide.Objectives Clinical and epidemiological characterization of MS patients in João Pessoa, Paraíba city.Methods Study involving patients treated in five services in the city.Results It included 87 patients with MS, representing a prevalence of 12.0 cases/100,000 pop...

Tissue kallikrein KLK1 and the kallikrein-related peptidases KLK2-15 are a subfamily of serine proteases that have defined or proposed roles in a range of central nervous system (CNS) and non-CNS pathologies. To further understand their potential activity in multiple sclerosis (MS), serum levels of KLK1, 6, 7, 8 and 10 were determined in 35 MS patients and 62 controls by quantitative fluorometr...

BACKGROUND The goal of this observational study was to examine the effect of common chronic medical conditions (CMCs) on long-term disability (activity limitation) in veterans already diagnosed with multiple sclerosis (MS). MATERIAL AND METHODS We retrospectively reviewed the electronic charts of 124 veterans with MS who have been regularly followed in our MS clinic for 10 or more years. Genera...

BACKGROUND Motor and somatosensory evoked potentials (MEPs and SSEPs) are sensitive tools for detecting subclinical lesions, assessing disease severity, and determining the prognosis for outcomes of patients with inflammatory neurological diseases such as multiple sclerosis. However, their roles in neuromyelitis optica (NMO), a severe inflammatory neurological disease that predominantly involve...

Abstract Objective The mini-Balance Evaluation Systems Test (BESTest) is a balance measure for assessment of the underlying physiological systems control in adults. Evaluations test–retest reliability mini-BESTest larger samples people with multiple sclerosis (MS) are lacking. purpose this study was to investigate total and section sum scores individual items mild moderate overall MS disability...

Background: Multiple sclerosis (MS) prevalence in Iraq is 11.73/100,000 it causes disability younger adults. Expanded Disability Status Scale (EDSS) can monitor MS while Visually Evoked Potentials (VEP) serves as a marker of myelination. Objectives: To explore the relationship between EDSS and VEPs multiple patients. Patients Methods: A cross-sectional study was conducted Ghazi Al- Hariri Hospi...