Seam cells in Caenorhabditis elegans provide a paradigm for the stem cell mode of division, with the ability to both self-renew and produce daughters that differentiate. The transcription factor RNT-1 and its DNA binding partner BRO-1 (homologues of the mammalian cancer-associated stem cell regulators RUNX and CBFβ, respectively) are known rate-limiting regulators of seam cell proliferation. He...

the present study was undertaken to investigate the beneficial effects of widely-prescribed lipid lowering drugs, pitavastatin, atorvastatin and simvastatin 3-hydroxy-3-methylglutaryl-coenzyme-a (hmg-coa) reductase inhibitors in cognitive dysfunctions of mice. intra-cerebroventricular (icv)-streptozocin-(stz)- and high-fat diet (hfd)-induced amnesia served as interoceptive memory models where a...

after the teacher, the most important factor in foreign language classroom is the textbook. it is vital that the best possible text be chosen for each situation. even with the development of new technologies that allow for higher quality teacher-generated materials, demand for textbooks continues to grow, and the publishing industry responds with new series and textbooks each year. therefore, i...

A computationally intelligent framework has been developed for the forced landing problem for uninhabited airborne vehicles (UAVs). This framework locates landing areas within an image that are of the appropriate geometrical size and free of obstacles. The surface-type of the candidate landing areas are classified into categories such as grass, trees and water. The classification results are co...

Purpose: Genu varum deformity changes the line of gravity from center of knee towards the medial side. This deviation results in changes in the upper part of the lower extremity that can affect postural control as well as the position and activity of the proximal muscles of the knee joint, like the gluteus medius muscle. Therefore this study aims to investigate the effect of genu varum disorder...

Landing gear is one of the critical subsystems of an aircraft. The need to design landing gear with minimum weight, minimum volume, high performance, improved life, and reduced life cycle cost have posed many challenges to landing gear designers and practitioners. Further, it is essential to reduce the landing gear design and development cycle time while meeting all the regulatory and safety re...

The present study is an attempt to investigate the way culture is addressed in ELT in Iran in general and the place of culture in ELT at the high school level of education in particular. Throughout the study, this issue was examined with reference to the relevant theoretical background, and the content analysis of prescribed English textbooks. The research findings make it clear that the curren...

Gene regulation during development is an important biological activity that leads to synthesis of biomolecules at specific locations and specific times. The single tropomyosin gene of Caenorhabditis elegans, tmy-1/lev-11, produces four isoforms of protein: two from the external promoter and two from the internal promoter. We investigated the internal promoter of tropomyosin to identify sequence...

Cis-regulatory elements (CREs) are crucial links in developmental gene regulatory networks, but in many cases, it can be difficult to discern whether similar CREs are functionally equivalent. We found that despite similar conservation and binding capability to upstream activators, different GATA cis-regulatory motifs within the promoter of the C. elegans endoderm regulator elt-2 play distinctiv...