Aim The aim of this review is to define the most pertinent animal models for periodontal research. Background In periodontal research, animal studies are complementary to in vitro experiments prior to testing new treatments. Animal models and cell cultures have contributed new knowledge in biological sciences, including periodontology. Although cultured cells can be used to study physiological ...

Background Type 2 diabetes and periodontitis predispose to a higher risk of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. Recent studies show upregulation innate immuno-regulatory microRNA-146a -155 in oral fluids patients with type as well periodontitis. The aim was investigate whether these microRNAs may relate patient susceptibility the infection via modulation SARS-C...

BACKGROUND AND AIMS This study was designed to explore the relationship between periodontitis and diabetes mellitus (DM) in Uygur adults from Xinjiang. METHODS AND RESULTS Data were obtained using questionnaire and oral examination. Participants (48.87 ± 13.72 yr) were categorized into periodontitis and non-periodontitis groups in accordance with the chronic periodontitis diagnostic criteria....

The glycoprotein milk fat globule-epidermal growth factor factor 8 (MFG-E8) is expressed in several tissues and mediates diverse homeostatic functions. However, whether it plays a role in bone homeostasis has not been established. In this study, we show for the first time, to our knowledge, that osteoclasts express and are regulated by MFG-E8. Bone marrow-derived osteoclast precursors from MFG-...

To evaluate whether periodontitis modulates lung inflammation in an experimental model of asthma as well as the photodynamic therapy (PDT) is associated with a reduction of lung inflammation. Seventy-two BALB/c male mice (~2 months) were randomly divided into 8 groups (n = 9): Basal, Periodontitis (P), P+PT, P+PT+PDT, Asthma (A), A+P, A+P+PT, and A+P+PT+PDT. Periodontitis was induced by using t...