Patents for the first generation of approved biopharmaceuticals have either expired or are about to expire. Thus the market is opening for generic versions, referred to as 'biosimilars' (European Union) or 'follow-on protein products' (United States). Healthcare professionals need to understand the critical issues surrounding the use of biosimilars to make informed treatment decisions.The compl...

References 1 UK Medical Eligibility Criteria for Contraceptive Use (UKMEC 2009). 2009. http://www.fsrh.org/admin/ uploads/UKMEC2009.pdf [Accessed 10 February 2010]. 2 UK Medical Eligibility Criteria for Contraceptive Use (UKMEC 2005/2006). 2006. http://www.fsrh.org/ admin /up loads /a rch ive /UKMEC2005_06.pd f [Accessed 10 February 2010]. 3 Gaffield ME, Kapp N, Curtis KM. COC and IUD use among...

We performed preoxygenation on 25 patients, aged 1-12 yr. End-tidal oxygen sampling was used to find the duration of preoxygenation required to reach an end-tidal oxygen fraction of 0.9. All children reached this end-point within 80 s, which was markedly more rapid than that observed in adult subjects. The clinical applications of this form of monitoring in children are discussed.

Biosimilars are currently popular after the expiry date of patents for biological reference products have expired or soon will expire. Besides, this ‘copycat’ version biologic offers much lower costs as compared to products, thus promoting better patient access treatment certain diseases such cancer, inflammatory diseases, skin disorders, and diabetes. This review aims determine differences bet...

The scope of this paper is to outline and discuss fundamental guidelines for an expired medication collection program for Brazil and to provide evidence supporting campaigns to raise the population's awareness for the program's success. It is a document-based descriptive review that analyzes official, technical and regulatory documents from Portugal, Canada and Colombia, where there are expired...