in this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (plga 50:50) and poly (lactide). the effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation efficiency...

Rosacea is a chronic inflammatory skin condition that predominantly affects the skin of the face and the eyes. Several factors are associated with the onset and persistence of the condition, including an altered immune response in the skin and elevated levels of Demodex mites. Alterations in the immune response include elevated levels of LL-37 in rosacea skin, increased expression of TLR-2 and ...

Several chemical changes in soil are associated with plant growth-promoting rhizobacteria (PGPR). Some bacterial strains directly regulate plant physiology by mimicking synthesis of plant hormones, whereas others increase mineral and nitrogen availability in the soil as a way to augment growth. Identification of bacterial chemical messengers that trigger growth promotion has been limited in par...

Purpose: To introduce a new myofascial release method named “roptrotherapy” that consists of deep cross-friction massage with the aid of a myofascial T bar (roptron). Description: The intervention of roptrotherapy consists of a 30-minute session, total, of deep-friction massage with the aid of a myofascial T bar. These bars are made of bronze, a neutral material to skin. The advantages of bronz...

the present investigation was aimed at developing a novel colon targeted system of lornoxicam based on the use of a combination of ph dependent system (to prevent the premature release of drug in the upper git) and enzymatically degradation system (to ensure the specificity of drug release in the colon). the drug loaded guar gum microspheres prepared by emulsification cross-linking method were ...

Sebum provides vital cutaneous functions including moisture retention and defense against the external environment, pathogens. Despite well-defined homeostatic of sebum in fortifying skin barrier, role microbiota-immune system axis regulation remains unclear. We have recently shown that keratinocyte-derived cytokine thymic stromal lymphopoietin (TSLP) promotes secretion through T cell stimulati...

The role of Ca in transmitter release and facilitation has been examined at the squid giant synapse by evaluating the effect of changes in the external concentration of Ca on the excitatory postsynaptic potential (EPSP). Changes in Ca were achieved by means of an arterial perfusion technique, circumventing the diffusion barrier that exists between the synapse and the bathing medium. Transmitter...