The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the collagen fibers. Fiber formation, via fibrillogenesis, can be controlled in vitro by several factor...

cate that Shh signalling controls Laminin gene expression, a critical step in the formation of the myotomal basement membrane, and that Laminin-111 has specific and essential role in myotomal basement membrane assembly. Together, our data reveal a novel role for Shh signalling in the control of basement membrane assembly and provide a framework for understanding the complex interactions between...

cate that Shh signalling controls Laminin gene expression, a critical step in the formation of the myotomal basement membrane, and that Laminin-111 has specific and essential role in myotomal basement membrane assembly. Together, our data reveal a novel role for Shh signalling in the control of basement membrane assembly and provide a framework for understanding the complex interactions between...

Super-dense transfected cell microarrays (TCMs) were created by a piezoelectric inkjet printer on a glass substrate that had been grafted with poly(ethylene glycol) (PEG). The micro-spots that contained plasmid and extra-cellular matrix (ECM) protein were separated from one another by a hydrophilic barrier generated by PEG. We successfully constructed the densest TCMs with spots of 50 μm in dia...

cate that Shh signalling controls Laminin gene expression, a critical step in the formation of the myotomal basement membrane, and that Laminin-111 has specific and essential role in myotomal basement membrane assembly. Together, our data reveal a novel role for Shh signalling in the control of basement membrane assembly and provide a framework for understanding the complex interactions between...

Honey's inherent compositional diversity, bio-compatibility and time tested therapeutic efficacy, especially in tissue repair as a topical agent, attract researchers towards harnessing its biomaterial potential particularly in developing matrix for tissue engineering applications. Hence, this study fabricates fibrous mat from optimum honey-alginate formulation and alginate solution using wet sp...