Forced expression of MN1 in primitive mouse hematopoietic cells causes acute myeloid leukemia and impairs all-trans retinoic acid-induced granulocytic differentiation. Here, we studied the effects of MN1 on myeloid differentiation and proliferation using primary human CD34(+) hematopoietic cells, lineage-depleted mouse bone marrow cells, and bipotential (granulocytic/monocytic) human acute myel...

BACKGROUND Loss of the tumor suppressor phosphatase and tensin homolog (PTEN) is frequently observed in hematopoietic malignancies. Although PTEN has been implicated in maintaining the quiescence of hematopoietic stem cells (HSCs), its role in hematopoiesis during ontogeny remains largely unexplored. METHODS The expression of hematopoietic marker genes was analyzed via whole mount in situ hyb...

Mammalian tissue- and/or time-specific transcription is primarily regulated in a combinatorial fashion through interactions between a specific set of transcriptional regulatory factors (TRFs) and their cognate cis-regulatory elements located in the regulatory regions. In exploring the DNA regions and TRFs involved in combinatorial transcriptional regulation, we noted that individual knockdown o...

Genetic variants affecting hematopoiesis can influence commonly measured blood cell traits. To identify factors that affect hematopoiesis, we performed association studies for blood cell traits in the population-based Estonian Biobank using high-coverage whole-genome sequencing (WGS) in 2,284 samples and SNP genotyping in an additional 14,904 samples. Using up to 7,134 samples with available ph...

In this paper, a directional bi-directional Soft-Output Viterbi algorithm (SOVA) based Turbo decoder architecture is proposed. By performing an extra pass through the decoder trellis, effectively bi-directional decoding, decoder performance can be improved. The bi-directional decoding results in a 60% increase in operations over the conventional SOVA decoder, while incurring no significant incr...

Though considerable effort has been expended on demonstrating the importance of extraretinal cues in distance perception (e.g. state of vergence), recent studies have shown that enriching the visual image brings about a decrease of perceptual underestimation of distance as observed otherwise, providing that contextual information is situated in the proximal space with regard to target position....

Epigenetic mechanisms such as DNA methylation are essential regulators of the function and information storage capacity of neurons. DNA methylation is highly dynamic in the developing and adult brain, and is actively regulated by neuronal activity and behavioural experiences. However, it is presently unclear how methylation status at individual genes is targeted for modification. Here, we repor...

We have extracted run-time memory access traces from the Mediabench benchmark set. These traces exhibit a high degree of repetition. We propose an adaptive bus coding scheme that will reduce transition activity by exploiting value repetition. For this scheme, we introduce an extra bitline similar to bus-invert coding.

C/EBPs are a family of transcription factors that regulate growth control and differentiation of various tissues. We found that C/EBPγ is highly upregulated in a subset of acute myeloid leukemia (AML) samples characterized by C/EBPα hypermethylation/silencing. Similarly, C/EBPγ was upregulated in murine hematopoietic stem/progenitor cells lacking C/EBPα, as C/EBPα mediates C/EBPγ suppression. S...

The purpose of this study is to investigate problems and barriers of greenhouse growers in Isfahan Province, Iran using the qualitative paradigm. Data were collected with semi-structured interviews and direct observations. Most participants were questioned by phone interview. The response rate to phone calls was 59.2 percent. Data are analyzed by the grounded theory. Structural analysis is util...