Message from the ISCB: The Bioinformatics Open Source Conference (BOSC) is a yearly meeting organized by the Open Bioinformatics Foundation (OBF), a non-profit group dedicated to promoting the practice and philosophy of Open Source software development and Open Science within the biological research community. BOSC has been run since 2000 as a two-day Special Interest Group (SIG) before the ann...

The Annual Bio-Ontologies Meeting has now reached its seventh consecutive year, running as a special interest group (SIG) of the much larger ISMB conference. This year's meeting in Glasgow had approximately 100 attendees. Since the advent of the Gene Ontology, which coincided with the first Bio-Ontologies Meeting, we have seen a year-on-year strengthening of the field; bio-ontologies has moved ...

Although considered a "joint disease," rheumatoid arthritis is associated with the involvement of extra-articular manifestations. The aim of the study is the investigation and comparison of frequency and type of extra-articular manifestations in a well defined community based cohort of patients with seropositive and seronegative rheumatoid arthritis. Using the ACR (1987) criteria for rheumatoid...

Would an ill person interact with an application the same way as a healthy person? Could a simulation of a chemical spill provide the same stressful environment for emergency response workers to give realistic feedback about the usability of a chemical spill assistant application? Researchers have noted [1, 2] that traditional laboratory usability studies are insufficient for mobile application...

This contribution is based on the four presentations made at the Special Interest Group (SIG) meeting titled Gene Expression in Fungi held during IMC9 in Edinburgh. This overview is independent from other articles published or that will be published by each speaker. In the SIG meeting, basic principles of in vivo animal models for virulence studies were discussed. Infection associated genes of ...

During two terms of a fluid power engineering course, four formative and summative course assessments, weekly e-mail feedback journals, midterm e-surveys, focus groups, and departmental student evaluation of instruction (SEI) forms, were used to assess student perceptions of their learning and the instruction methods used. The weekly e-mail feedback journals and midterm e-surveys enabled severa...

OBJECTIVE To evaluate if clinical and laboratory parameters could assist in the differential diagnosis of intra and extra-hepatic neonatal cholestasis (NC). METHODS Retrospective study of NC patients admitted at the Pediatric Hepatology Outpatient Clinic of the teaching hospital of Universidade Estadual de Campinas (UNICAMP), Campinas, Brazil, between December 1980 and March 2005. The approac...