In an open-label study, the concentrations of azithromycin in middle ear effusions and plasma were determined in 29 children between 1 and 8 years of age with a diagnosis of either secretory otitis media of at least 1 month's duration or acute otitis media. Azithromycin (10 mg/kg) was administered as a single dose 12, 24 or 48 h before the insertion of tympanostomy tubes to 17 children with sec...

OBJECTIVES To identify the common presentation(s) and the clinical and operative finding(s) in patients with cholesteatomatous and long-term noncholesteatomatous chronic suppurative otitis media and to adapt a surgical management best suited to ensure long-term safety in these Papua New Guinean patients for whom postoperative follow-up is minimal. DESIGN Retrospective case series. SETTING P...

The occurrence of mast cells is studied in the normal facial nerve and in the facial nerve post mortem exam of patients with chronic suppurative otitis media without associated facial paralysis. A small number of mast cells were found in the normal facial nerve. These cells were usually located in close proximity to the endoneural and epineural blood vessels. The number of mast cells was i...

The inner and middle ear are connected mainly through round and oval windows, and inflammation in the middle ear cavity can spread into the inner ear, which might induce a disturbance. In cases with intractable otitis media, attention should also be paid to symptoms related to the inner ear. In this paper, middle ear inflammation and related inner ear disturbances are reviewed with a focus on r...

Twenty-nine patients with chronic suppurative otitis media with intracranial complications are reviewed. The complications occurred predominantly in young patients with a mean age of 17 years. The most common complication was brain abscess (n = 20). The others were meningitis (n = 3), subdural abscess (n = 3), perisinus abscess (n = 2) and otitic intracranial hypertension (n = 1). The common pa...

This reference guide contains highlights from the Clinical Practice Guideline, Otitis Media with Effusion in Young Children. The Otitis Media Guideline Panel, a private-sector panel of health care providers, developed the Guideline after comprehensively analyzing the research literature and current scientific knowledge of the development, diagnosis, and treatment of otitis media with effusion i...

OBJECTIVE To review the literature concerning the impact of otitis media on language acquisitions in children. SOURCES OF DATA Medline. The following keywords were used for searching: otitis media, hearing, language and children. SUMMARY OF THE FINDING: The hearing loss observed in otitis media may be a result of: 1) structural disorders in the middle ear; 2) ultrastructural lesions and bioch...

Acute mastoiditis, an infectious inflammatory process in the temporal bone, is an uncommon complication of otitis media. Here we describe a fatal case of mastoiditis complicated by thrombosis of the sigmoid sinus and intracerebral abscess caused by an unusual pathogen (Nocardia asteroides) in a person with HIV infection. Sulfonamides have remained the first-line agents for the management of Noc...