نتایج جستجو برای: fabp5
تعداد نتایج: 302 فیلتر نتایج به سال:
The principle endocannabinoids are 2-acylglycerol esters, such as 2-arachidonoylglycerol (2-AG), and N-acylethanolamines, anandamide (N-arachidonoylethanolamine, AEA). glycerol esters ethanolamides synthesised hydrolysed by parallel, independent pathways. Mechanisms for release re-uptake of unclear, although potent selective inhibitors facilitated diffusion across cell membranes have been devel...
Niemann-Pick disease, type C1 (NPC1) is a fatal, neurodegenerative disorder for which there is no definitive therapy. In NPC1, a pathological cascade including neuroinflammation, oxidative stress and neuronal apoptosis likely contribute to the clinical phenotype. While the genetic cause of NPC1 is known, we sought to gain a further understanding into the pathophysiology by identifying different...
OBJECTIVE The adipocyte/macrophage fatty acid-binding proteins aP2 (FABP4) and Mal1 (FABP5) are intracellular lipid chaperones that modulate systemic glucose metabolism, insulin sensitivity, and atherosclerosis. Combined deficiency of aP2 and Mal1 has been shown to reduce the development of atherosclerosis, but the independent role of macrophage Mal1 expression in atherogenesis remains unclear....
PURPOSE To determine the expression of hepatic L-FABP and intestinal I-FABP in an experimental model of necrotizing enterocolitis (NEC) in neonatal rats. METHODS Newborn Sprague-Dawley rats were divided into four groups: Control (C1) - exclusive breastfeeding at the first and sixth procedures (C6), NEC1 - fed formula milk and submitted to hypoxia and hypothermia at the first and sixth procedu...
Purpose: Actinic keratosis (AK) is a premalignant lesion that has 1-10% potential of progression to squamous cell carcinoma (SCC). The purpose this study was non-invasively collect skin samples from subjects with lesions clinically suspicious for AK and SCC identify genes may indicate the likelihood progressing SCC. Materials Methods: Skin were collected adhesive patch kits prior biopsy RNA iso...
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