abstract background the aim of the present study was to determine the endocrine dysfunction in patients with major thalassemia, who receive hyper transfusion. materials and methods this cross sectional study was performed during one year, which included 65 major thalassemia patients (31 females and 34 males), aged between 14 month to 27 years old (median 10,3). growth assessment was measured by...

BACKGROUND This study investigated postpartum metabolic abnormality in women with previous gestational diabetes mellitus (GDM) and predictive factors for postpartum glucose intolerance. METHODS From March 2001 to February 2003, 127 prior-GDM women underwent a 75g oral glucose tolerance test (OGTT) and metabolic assessment at least six weeks after delivery. To identify the predictors, clinical...

OBJECTIVE Most animals experience fasting-feeding cycles throughout their lives. It is well known that the liver plays a central role in regulating glycogen metabolism. However, how hepatic glycogenesis is coordinated with the fasting-feeding cycle to control postprandial glucose homeostasis remains largely unknown. This study determines the molecular mechanism underlying the coupling of hepati...

BACKGROUND To evaluate the clinical efficacy of sitagliptin for reducing plasma glucose levels in Korean subjects with type 2 diabetes mellitus during a 14-week treatment period. METHODS Our study design involved the addition of 100 mg sitagliptin once-daily to three ongoing combination therapy regimens and changing from glimepiride and metformin to sitagliptin and metformin. RESULTS The ad...

OBJECTIVE One putative benefit of hormone replacement therapy (HRT) is a reduced risk of diabetes or reduced fasting glucose level. We report here the association of HRT with proinsulin, insulin, and fasting and postchallenge glucose levels in older adults. RESEARCH DESIGN AND METHODS Current HRT use was validated and cross-sectionally compared with diabetes-related variables in 785 women wit...

introduction: ramadan is the ninth month of the lunar islamic calendar, during which muslims are obliged to perform specific rites and rituals. fasting is considered the most important ritual during the holy month of ramadan. fasting variably influences the health of individuals, which could be attributed to the changes in the concentrations of certain biochemical markers. this study aimed to e...

G lucokinase catalyzes glucose to glucose -6-phosphate conversion in the pancreatic ␤-cell and is a key regulator of insulin secretion (1). The glucoki-nase gene (GCK) on chromosome 7p15.3–15.1 has 12 exons. GCK het-erozygous inactivating mutations result in mild fasting hyperglycemia termed maturity onset diabetes of the young type 2 (MODY2) or MODY-GCK (MIM # 125851) (2). The mutations result...

OBJECTIVE Elevated fasting glucose level is associated with increased carotid intima-media thickness (IMT), a measure of subclinical atherosclerosis. It is unclear if this association is causal. Using the principle of Mendelian randomization, we sought to explore the causal association between circulating glucose and IMT by examining the association of a genetic risk score with IMT. RESEARCH ...

Results There were 54 obese children, mean age 12.2 (11.9 to 12.5) years. Thirty seven (68.5%) boys and 17 (31.5%) girls. With 34 children (63%) had insulin resistance: 23 (67.6%) male sex, and 11 (32.4%) girls, 18 (52.9%) no history of diabetes mellitus in families and 16 (47.1%) were found in the family history of diabetes mellitus. The average fasting blood glucose level on average obese chi...

BACKGROUND Randomized trials of postmenopausal hormone therapy have found differing effects on fasting glucose levels. No trial has evaluated the effect of hormone therapy on diabetes incidence. OBJECTIVE To evaluate the effect of hormone therapy on fasting glucose level and incident diabetes. DESIGN Randomized, double-blind, placebo-controlled trial. SETTING 20 U.S. clinical centers. P...