mitochondria play key roles in many cell functions including energy production, fatty acid metabolism, pyrimidine biosynthesis, calcium homeostasis, and aging. they also regulate crucial signaling cascades such as apoptosis and oxidative stress. the proteome is often used to investigate the functional correlations on protein levels. based upon the human, genome there is estimated 2000 to 2500 a...

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objective(s): to understand the role of mitochondrial respiration in cisplatin sensitivity, we have employed wild-type and mitochondrial dna depleted rho0 yeast cells. materials and methods: wild type and rho0 yeast cultured in fermentable and non-fermentable sugar containing media, were studied for their sensitivity against cisplatin by monitoring growth curves, oxygen consumption, ph changes ...

oxidative stress and mitochondrial dysfunction are the main suggested mechanisms for neurodegenerative diseases. in this study, we have evaluated the effects of epicatechin (ec) on mitochondrial damage induced by homocycteine (hcy) using isolated rat hippocampus mitochondria in vivo . ec (50 mg/kg) was gavaged daily for a period of 10 days, starting 5 days prior to hcy (0.5 μmol/μl) intra hippo...

Umbilical cord compression (UCC) sufficient to reduce umbilical blood flow by 30% for 3 days, results in increased fetal plasma cortisol and catecholamines that are likely to promote maturation of the fetal lung and brown adipose tissue (BAT). We determined the effect of UCC on the abundance of uncoupling protein (UCP)1 (BAT only) and -2, glucocorticoid receptor (GR), and 11beta-hydroxysteroid ...

prohibitins are chaperone proteins highly conserved among eukaryotes. many different functions have been attributed to prohibitins depending on their tissue expression and sub-cellular localization. prohibitins play a major role in mitochondrial physiology, regulating the stability and the processing of both respiratory chain complex subunits and opa1, a mitochondrial fusion regulating protein....

multiple sclerosis (ms) is a chronic inflammatory demyelinating disease of the central nervous system that inflammation, demyelination, oligodendrocyte loss, gliosis, axonal injury and neurodegeneration are the main histopathological hallmarks of the disease. although ms was classically thought as a demyelinating disease, but axonal injury occurs commonly in acute inflammatory lesions. in ms mi...

The purpose of this work is to compare the properties of phosphatidate phosphatase (L-alpha-phosphatidate phosphohydrolase, EC 3.1.3.4) in fetal and adult rat lung and to establish the developmental profile of activity measured under optimal conditions. The maximal pH of 6.0--7.0 and the inhibition by fluoride, Ca2+ and detergents were simialr for both adult and fetal. Phosphatidate phosphohydr...

The present study aimed to compare the ultra structural features of endothelial cells of fetal terminal capillaries of placentae from hypertensive (n=10) and non-hypertensive (n=10) pregnancies. The ultrastructural features of endothelial cells of terminal capillaries from the fetal surface of each placenta were examined under the electron microscope. Micrographs of 8 different endothelial cell...