413 Indian Journal of Dermatology 2014; 59(4) the patient may have taken, or due to the coloring agent titanium dioxide present in the tablet of levocetirizine. However, detailed history taking excluded possibility of both, as there was no other drug intake during last 4 weeks. Also, the patient did not develop any reaction on provocation with fexofenadine, which contained titanium dioxide. The...

The purpose of the present study was to comparatively evaluate the effect of newer antihistamines on psychomotor functions in Indian population. Seventy five patient volunteers were included in the study. Volunteers were put into 5 groups based on the type of antihistamine prescribed. Group-1 volunteers included those who were prescribed no antihistamine, group-2 were prescribed first generatio...

This article reviews the molecular biology of the interaction of histamine with its H1-receptor and describes the concept that H1-antihistamines are not receptor antagonists but are inverse agonists i.e. they produce the opposite effect on the receptor to histamine. It then discourages the use of first-generation H1-antihistamines in clinical practice today for two main reasons. First, they are...

Clinical reports have shown that some antihistamines, such as ketotifen, occasionally produced seizures, especially in pre-school age children or young patients with epilepsy. The purpose of this study was to investigate whether olopatadine, one of the most efficacious antihistamines, promotes seizures induced by electroshocks in young rats. We investigated the seizures induced by electroshock ...

Background In Japan, information of daily airborne Japanese cedar pollen counts is made public during pollen season. If symptoms severity and treatment outcome are predictable according to these pollen counts, management of seasonal allergic rhinitis may become more precise. Aims of the study To evaluate the relationship between airborne pollen counts, symptoms severity and treatment outcome in...

A validated simple, economic, selective, and stability indicating spectrofluorimetric method was developed for the determination of some antihistaminic H1 receptor antagonist drugs namely ebastine (EBS), cetirizine dihydrochloride (CTZ), and fexofenadine hydrochloride (FXD). The method is based on the reaction of the cited drugs with 2-cyanoacetamide in alkaline medium to give highly fluorescen...

First-generation antihistamines can have adverse effects on the central nervous system and thereby complicate discharge planning from the emergency department (ED). Newer antihistamines are potentially safer, causing less sedation with similar efficacy. The aim of this study was to review the literature to better define which antihistamines are good options for the treatment of acute allergic r...