نتایج جستجو برای: fibrinogen
تعداد نتایج: 14076 فیلتر نتایج به سال:
BACKGROUND Normalization of plasma fibrinogen levels may be associated with satisfactory haemostasis and reduced bleeding. The aim of this retrospective study was to assess fibrinogen recovery parameters after administration of fibrinogen concentrate (Haemocomplettan P) to patients with diffuse bleeding in cardiovascular surgery. Data on transfusion and patient outcomes were also collected. M...
Fibrinogen, 1 of 13 coagulation factors responsible for normal blood clotting, is synthesized by hepatocytes. Detailed roles of the orphan nuclear receptors regulating fibrinogen gene expression have not yet been fully elucidated. Here, we identified estrogen-related receptor gamma (ERRγ) as a novel transcriptional regulator of human fibrinogen gene expression. Overexpression of ERRγ specially ...
Rat fibrinogen has been purified and compared with bovine and human fibrinogen with respect to a number of chemical characteristics, including molecular size, charge distribution, NH2-terminal amino acids, total amino acid composition, and interspecies immunological cross-reactivity. Although human and bovine fibrinogen demonstrated three nonidentical polypeptide chains by sodium dodecyl sulfat...
Hereditary fibrinogen abnormalities comprise two classes of plasma fibrinogen defects: Type I, afibrinogenemia or hypofibrinogenemia, which has absent or low plasma fibrinogen antigen levels (quantitative fibrinogen deficiencies), and Type II, dysfibrinogenemia or hypodysfibrinogenemia, which shows normal or reduced antigen levels associated with disproportionately low functional activity (qual...
The integrin αIIbβ3 on resting platelets can bind to immobilised fibrinogen resulting in platelet spreading and activation but requires activation to bind to soluble fibrinogen. αIIbβ3 is known to interact with the general integrin-recognition motif RGD (arginine-glycine-aspartate) as well as the fibrinogen-specific γ-chain dodecapeptide; however, it is not known how fibrinogen binding triggers...
We identified a patient with novel heterozygous variant fibrinogen, γp.C352R (Niigata II; N-II), who had bleeding episode and failed infertility treatment was suspected to have hypodysfibrinogenemia based on low discordant fibrinogen levels (functional assay 0.33 g/L, immunological 0.91 g/L). analyzed the mechanism of this rare phenotype congenital disorder. Patient plasma purified protein char...
BACKGROUND & OBJECTIVES The comparative prognostic value of C-reactive protein (CRP) and fibrinogen for cardiovascular events has been inconclusively investigated. t0 his study was carried out to compare the prognostic value of CRP versus fibrinogen in patients with coronary artery disease (CAD). METHODS The study included 13,100 patients with coronary angiography-confirmed CAD. Plasma CRP an...
Studies with (125)I-fibrinogen after the administration of phenformin plus ethyloestrenol in five subjects showed no evidence of enhanced catabolism of fibrinogen despite a fall in plasma fibrinogen concentration and shortened clot lysis time. It seems probable that the fall in plasma fibrinogen concentration after the administration of these drugs is related to diminished hepatic synthesis of ...
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