Sex steroids influence the growth of mammalian uterine tissues and the proto-oncogenes c-fos and c-jun have been implicated in the cascade of cellular events induced by the cyclic influence of oestrogen and progesterone. To investigate the role of these proto-oncogenes for fibroid growth their mRNA expression was measured in myometrium and fibroids under different hormonal conditions, using a s...

Failure to become and remain pregnant after IVF depends on multiple factors including but not limited to the ability of the uterus to implant embryo and to carry a pregnancy to term. One of the factors which adversely affect fertility is the presence of uterine fibroids [1]. The closer the fibroids are to the uterine cavity, the greater their effect is on female fertility [2]. Reproduction is a...

Background/introduction T2 signal intensity and perfusion MR findings are known to be important influencing factors for therapeutic response of uterine fibroids to MR-guided high-intensity focused ultrasound (MR-HIFU) ablation. While T2 signal intensity of fibroids is easy to assess, perfusion MRI is relatively difficult to perform. The aim of this study was to evaluate relationships between T2...

Uterine fibroids are the commonest benign tumours of women and affect all races with a cumulative lifetime risk of around 70%. Despite their high prevalence and the heavy economic burden of treatment, fibroids have received remarkably little attention compared to common female malignant tumours. This article reviews recent progress in understanding the biological nature of fibroids, their life ...

Background/introduction With regards to MR-HIFU ablation of uterine fibroids, there have been no screening MR criteria that comprehensively consider multiple influencing factors. The aims of this study was to generate screening MRI-based prediction model for therapeutic responses of MR-guided high-intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids comprehensively considering mu...

INTRODUCTION Uterine leiomyomas are the most common benign gynecologic tumors. To date laparoscopy myomectomy is the gold standard for treatment of symptomatic fibroids in reproductive-aged women. Detailed counseling about the effects of this procedure on postoperative sexuality and quality of life is important in these patients. However, available data on these subjects are limited and contrad...

Uterine leiomyomas/fibroids are the most common pelvic tumors of the female genital tract. The initiators remaining unknown, estrogens and progesterone are considered as promoters of fibroid growth. Fibroids are monoclonal tumors showing 40-50% karyo-typically detectable chromosomal abnormalities. Cytogenetic aberrations involving chromosomes 6, 7, 12 and 14 constitute the major chromosome abno...

Uterine leiomyoma is the most common uterine neoplasm of women. The latest statistics confirm that uterine leiomyomas are present in 20-50% women of reproductive age [1]. Indeed, they are found in up to 77% of women if the uterus is examined closely at autopsy [2]. The incidence of uterine leiomyomas in pregnancy varies from 1.6% to 10.7% according to the trimester of assessment and the size th...

Thioredoxin is a small multifunctional protein which acts as a dithiol hydrogen donor for ribonucleotide reductase in DNA synthesis. Thioredoxin participates in the regulation of different metabolic processes, such as changes in the activity of different enzymes, receptors or transcription factors. The aim of the present study was to determine possible differences in the expression of thioredox...

Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a non-invasive treatment approach for symptomatic uterine fibroids. One imaging characteristic considered in selecting patients who may benefit from MRgFUS of their uterine fibroids is the signal intensity of the fibroid compared with surrounding myometrium on T2-weighted MR images. Previous reports suggest that hyper-intense fibr...