BACKGROUND/OBJECTIVE Plasma-creatinine-based equations to estimate the glomerular filtration rate are recommended by several clinical guidelines. In 2009, Schwartz et al. adapted the traditional Schwartz equation to children and adolescents but did not find different k-coefficients between children and adolescents (k = 36.5 for all patients). We reevaluated the coefficient of the 2009-Schwartz ...

Darunavir is an efficacious drug; however, pharmacokinetic variability has been reported. The objective of this study was to find predisposing factors for low darunavir plasma concentrations in patients starting the once- or twice-daily dosage. Darunavir plasma concentrations from January 2010 till December 2014 of human immunodeficiency virus-infected individuals treated in the outpatient clin...

From the Division of Nephrology, Tufts– New England Medical Center, Boston (L.A.S., A.S.L.); the Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore (J.C.); and the Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland (T.G.). Address reprint requests to Dr. Stevens at Tufts– New England Medical Center, 750 Washington St., Box 391, Boston, MA 0...

BACKGROUND Multiple factors influence timing of dialysis initiation. The impact of supply of nephrology workforce on timing and incidence of dialysis initiation is not well known. METHODS We determined the number of pediatric and adult nephrologists in each state using data from the American Medical Association and American Boards of Internal Medicine and Pediatrics. We ascertained state popu...

BACKGROUND AND OBJECTIVES The level of glomerular filtration rate at which hemoglobin declines in chronic kidney disease is poorly described in the pediatric population. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This cross-sectional study of North American children with chronic kidney disease examined the association of glomerular filtration rate, determined by the plasma disappearance of...

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The uniqueness of carboplatin as a chemotherapy drug is in the fact that the systemic drug exposure produced by any dose in a patient can be reasonably estimated on the basis of his or her renal function. Calvert’s formula (1) of delivering a calculated dose in terms of target carboplatin area under the time– concentration curve (AUC) and a measured or estimated glomerular filtration rate (GFR)...