Phase I dose-finding studies aim at identifying the maximal tolerated dose (MTD). It is not uncommon that several are conducted, although often with some variation in administration mode or panel. For instance, sorafenib (BAY 43-900) was used as monotherapy least 29 phase trials according to a recent search clinicaltrials.gov. Since toxicity may be directly related specific indication, synthesi...

Once again, another year has passed and it has again been a difficult one for people who work in IT. Jobs continue to disappear altogether or are outsourced, although that trend is beginning to slow and in some cases is even reversing. Many of the companies who rushed to outsource are finding that their actual savings are less than anticipated and in a few cases nonexistent. Some companies who ...

mortality among subjects 65 and older with hemoglobin levels even in the “normal range,” is intriguing, in other studies2,3 confounding comorbid conditions accounted for most or all of the difference between anemic and nonanemic groups. Furthermore, even if 22% of the population were at risk for early demise because their hemoglobin levels were found to be low, it would remain to be shown that ...

Sometimes the quality of a process or product is described by a functional relationship between a response variable and one or more explanatory variables referred to as profile. In most researches in this area the response variable is assumed to be normally distributed; however, occasionally in certain applications, the normality assumption is violated. In these cases the Generalized Linear Mod...

— Although Face detection is not a recent activity in the field of image processing, it is still an open area for research. The greatest step in this field is the work reported by Viola and its recent analogous is Huang et al. Both of them use similar features and also similar training process. The former is just for detecting upright faces, but the latter can detect multi-view faces in still g...

Many real-world domains require that agents plan their future actions despite uncertainty, and that such plans deal with continuous space states, i.e. states with continuous values. While finitehorizon continuous state MDPs enable agents to address such domains, finding an optimal policy is computationally expensive. Although previous work provided approximation techniques to reduce the computa...