HYPOTHESIS The use of albumin in the early resuscitation formula after major burn has been forbidden because of its damaging effect on the gut barrier function. We hypothesize that inhibition of the inducible isoform of nitric oxide synthase to stabilize endothelial permeability and to retain albumin in the vascular space will ameliorate the major trauma-induced gut barrier dysfunction. DESIG...

Advances in burn care have a long history with accelerated development within the last 50 years. The principal areas of burn treatment include dressings, antimicrobials, fluid resuscitation, burn wound excision, grafting of skin, and skin substitution. This review presents a historical outline of these areas, their current status, and prospects for the future of burn care.

Severe burn injury evokes hypermetabolism and muscle wasting, despite nominally adequate nutrition. Although there is much information on whole organism and isolated tissue metabolism after burn injury, data examining regional burn hypermetabolism in vivo are lacking. Using surgically implanted (general anesthesia) regional vascular catheters and primed constant infusion of l-[1-(13)C]phenylala...

Care of burn-injured patients requires knowledge of the pathophysiologic changes affecting virtually all organs from the onset of injury until wounds are healed. Massive airway and/or lung edema can occur rapidly and unpredictably after burn and/or inhalation injury. Hemodynamics in the early phase of severe burn injury is characterized by a reduction in cardiac output and increased systemic an...

conclusions the potential to form biofilm correlated with antibiotic resistance and ampc production in non-burn burn isolates of a. baumannii. on the other hand, the burn strains produced significantly higher amounts of esbl yet biofilm production was unrelated to antibiotic resistance or esbl-production. materials and methods sixty isolates of a. baumannii were employed of which, 30 were burn ...

In this paper a new method is described for estimating the fire interval distribution of a region using spatial-temporal fire history data. In Los Angeles County, California, detailed information on fires has been available through the use of geographic information systems (GIS) technology. The proposed estimator is applied to GIS data covering the years 1878–1996 and it is shown that fuel age ...

Each summer in Australia, bushfires burn many hectares of forest, causing deaths, injuries, and destroying property. Agent-based simulation is a powerful tool for decisionmakers to explore different strategies for managing such crisis, testing them on a simulated population; but valid results require realistic underlying models. It is therefore essential to be able to compare models using diffe...

Burns commonly occur in children and their first aid remains inadequate despite burn prevention programmes. While scald injuries predominate, contact and flame burns remain common. Although typically less severe injuries overall than those in adults, hypertrophic scarring complicating both the burn wound and even donor sites occur more frequently in children. The heterogeneous nature of burn wo...

"American Burn Association Practice Guidelines for Prevention, Diagnosis, and Treatment of Ventilator-Associated Pneumonia in Burn Patients" was published to provide recommendation for the prevention, diagnosis, and treatment of ventilator-associated pneumonia in burn patients. This article makes interpretations and conclusions for prevention, diagnosis and treatment from this guideline in the ...

Burn units provide a unique set of resources to patients with complex wounds, sepsis, and organ failures. This resource set is useful in a number of traumatic, infectious, and medical conditions as well. Further, many burn patients have sustained simultaneous non-burn trauma which will be managed in burn programs.