Study aims to design a Gastro retentive Drug Delivery System of Cefuroxime axetil (CA). CA is a broad spectrum beta lactam type of antibiotic. More specifically, it is a second-generation cephalosporin. CA has site specific absorption from upper gastro intestinal tract and in intestine it undergoes hydrolysis to cefuroxime having poor absorption. Unabsorbed drug causes high concentration of ant...

Purpose. Effective Helicobacter pylori eradication requires delivery of the antibiotic locally in the stomach. High dose of amoxicillin (750 to 1000 mg) is difficult to incorporate in floating tablets but can easily be given in liquid dosage form. Keeping the above facts in mind, we made an attempt to develop a new floating in situ gelling system of amoxicillin with increased residence time usi...

Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in past decades. These are low density that float over gastric contents and remain buoyant stomach for a prolonged period time without affecting emptying rate. GRFDDS is used to delay residence stomach. The controlled retention solid...

Purpose: To develop a floating multiparticulate unit system for metoprolol tartarate, using a porous carrier, with an outcome for delayed gastric emptying. Methods: Dried microparticles of metoprolol tartarate were prepared by solvent evaporation using Eudragit ® RS-PO, polypropylene foam powder, and dichloromethane as release-rate modifying polymer, floating aid and solvent respectively. The s...

During the past few decades, numerous oral drug delivery systems have been developed to act as drug reservoirs from which the active substance can be released over a specific period of time at a predetermined and controlled rate. It is evident from the recent scientific and patent literatures that an increased interest in novel oral controlled release dosage forms that designed to be retained i...

The present study was to prepare a gastro retentive drug delivery system of Losartan floating tablets, was designed to increase the gastric residence time, thus prolong the drug release. The different type formulations were prepared by using polymers like HPMC K100M, ethyl cellulose, talc and lactose. In the present study Sodium bicarbonate and citric acid were incorporated as a gas generating ...

To prolong the residence time of dosage forms within the gastrointestinal tract until all drug is released at the desired rate is one of the real challenges for oral controlled-release drug delivery systems. This study was designed to develop a controlled-release floating matrix tablet and floating raft system of Mebeverine HCl (MbH) and evaluate different excipients for their floating behavior...