background and purpose: candida species constitute an important group of opportunistic fungi, which cause various clinical diseases. considering the resistance of some candida species to conventional antifungal agents, treatment of such cases may be challenging and complicated. the purpose of this study was to evaluate and compare the antifungal activities of euphorbia macroclada latex and fluc...

-Background:Candida species have emerged as successful pathogens worldwide and are associated with immunocompromised patients. Additionally, there is increasing resistance of Candida species to antifungal agents, and this has greatly contributed to the high morbidity and mortality amongst affected patients. In Zambia, little is known about the distribution of Candida species and their antifunga...

OBJECTIVES Candidiasis can be associated with the formation of biofilms on bioprosthetic surfaces and the intrinsic resistance of Candida albicans biofilms to the most commonly used antifungal agents has been demonstrated. In this study, we report on the antifungal activity of caspofungin at two different concentrations, on C. albicans and Candida parapsilosis biofilms with different ages of ma...

In this study, we found that ambroxol hydrochloride (128 μg/mL) exhibits synergistic antifungal effects in combination with fluconazole (2 μg/mL) against resistant planktonic Candida albicans (C. albicans) cells. This combination also exhibited synergistic effects against resistant C. albicans biofilms in different stages (4, 8, and 12 h) according to the microdilution method. In vitro data wer...

INTRODUCTION Historically, Candida albicans has represented the most common cause of candidemia. However, the proportion of bloodstream infections due to non-albicans Candida species has increased. Because of the risk for candidemia in intra-abdominal surgical patients, some experts advocate the use of fluconazole prophylaxis. The impact of this practice on the distribution of Candida species i...

conclusions our findings indicate that resistance of c. albicans strains to azoles is more common in tokat, turkey. therefore, a strategy to control the inappropriate and widespread use of antifungal drugs is urgently needed. fungal culturing and antifungal susceptibility testing will be useful in patient management as well as resistance surveillance. materials and methods a total of 201 c. alb...

The prophylactic use of fluconazole is common in blood and marrow transplant (BMT) recipients. To evaluate how fluconazole has influenced the development of azole resistance and candidemia, weekly mouthwashings were done, and fluconazole susceptibility was determined for 1475 colonizing and invasive isolates obtained from patients undergoing BMT. Of 585 patients, 256 (44%) were colonized with C...

OBJECTIVE To evaluate the role of Fluconazole in the management of neonatal systemic candidiasis. DESIGN Descriptive, retrospective analysis. SUBJECTS 23 neonates diagnosed as systemic candidiasis based on clinical suspicion with blood and/or urine culture positive for candida were treated with Fluconazole (5 mg/kg/day) for > 7 days. RESULTS Babies had mean birth weight 1590 + 533 g, mean...

The aim of this study was to investigate the susceptibility of the different phenotypes of Candida albicans strains isolated from clinical specimens to three antifungal agents, fluconazole, itraconazole and voriconazole. Totally 215 specimens were collected from oropharyngeal, gastrointestinal and urogenital tracts of non-neutropenic patients who had received no previous prophylactic treatment....

BACKGROUND AND PURPOSE Candidiasis is a major fungal infection, and Candida albicans is the major cause of infections in humans. The Clinical and Laboratory Standards Institute (CLSI) developed new breakpoints for antifungal agents against C. albicans. In this multi-center study, we aimed to determine the drug susceptibility profile of C. albicans, isolated from Iranian population according to ...