The bacillus of glanders may be so modified in virulence as to produce experimentally lesions differing widely in their histological features. The highly virulent culture causes primary necrosis and disintegration of the tissue followed by the invasion of the injured area by polymorphonuclear leucocytes. The bacilli of moderate virulence give rise to a primary lesion of an acute inflammatory na...

The role of pathology in the diagnosis of sarcoidosis is identification of granulomas in tissue specimens and performance of studies to exclude known causes of granulomatous inflammation. The granulomas of sarcoidosis are nonspecific lesions that, by themselves and in the absence of an identifiable etiologic agent, are not diagnostic of sarcoidosis or any other specific disease. Among the disea...

background: sub-acute bacterial endocarditis (sbe) rarely presents with features of a small vessel vasculitis. patients with sbe can also develop multiple serological abnormalities including anca. in this report, we present a case of infective endocarditis mimicked anca associated glomerulonephritis.case presentation: a 57-year old male with a clinical picture of rapidly progressive renal failu...

osteosarcoma (osteogenic sarcoma: os) is the most common primary malignant bone tumor of long bones, whereas primary osteosarcoma of chest wall, especially in sternum, is extremely rare. we report a 57-year-old man with an immobile slow growing mass located in the middle of the sternum. the patient had no significant pain or tenderness and the past medical history was not remarkable. ct-scan sh...

The ability of MR to detect CNS lesions in AIDS patients was evaluated by postmortem scanning of 10 formalin-fixed brains. Nine patients had premortem mental status changes and five had focal neurologic deficits. The brains were imaged and sectioned in corresponding planes. MR images showed atrophy in eight of the 10. All grossly identified lesions and areas of MR abnormality were histologicall...

Lipoxin A4 can alleviate cerebral ischemia/reperfusion injury by reducing the inflammatory reaction, but it is currently unclear whether it has a protective effect on diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury. In this study, we established rat models of diabetes mellitus using an intraperitoneal injection of streptozotocin. We then induced focal cerebral ischem...

A 48-year-old woman underwent total abdominal hysterectomy with conservation of the ovaries and tubes. Histology showed a well-circumscribed smooth muscle tumor with foci of degeneration (including infarct-type necrosis) but no coagulative tumor cell necrosis and only mild focal cytological atypia. She presented, 24 years later with shortness of breath and abdominal distension and underwent bil...