While early success rates using in vitro fertilisation ranged from 10% to 15%, improved technology has more than doubled that rate, owing to the availability of recombinant follicle-stimulating hormone, improved ovarian stimulation protocols, and assisted fertilisation technology. This latter technology has already revolutionised the management of male-factor infertility. The future goal is to ...

background: leukemia inhibitory factor (lif) is a pleiotropic cytokine of interleukin-6 family with a remarkable range of biological actions such as proliferative effects on the granulosa and theca cells. the aim of this study was to evaluate the effects of lif on the growth and maturation of mouse fresh and vitrified preantral follicles, an in vitro model was developed. methods: the ovaries of...

The authors report the generation, structure and function of a fully humanized, humanized antibody that profoundly inhibits follicle-stimulating hormone (FSH) actions in cell-based assays. Administration to ovariectomized mice prevented bone loss also accumulation adipose tissue when fed high-fat diet (HFD).

background: stroke is the third leading cause of death. hypothermia has been recognized as an effective method in reducing brain injury. in this study, we assessed the effects of granulocyte colony-stimulating factor (g-csf) as a neuroprotective agent and mild hypothermia on mortality, behavioral function, infarct volume, and brain edema in wistar rats. methods: forty male rats were used in fiv...