BACKGROUND Inhaled bronchodilators can increase exercise capacity in chronic obstructive pulmonary disease (COPD) by reducing dynamic hyperinflation, but treatment is not always effective. This may reflect the degree to which the abdomen allows dynamic hyperinflation to occur. METHOD A double blind, randomised, crossover trial of the effect of 5 mg nebulised salbutamol or saline on endurance ...

PURPOSE To investigate the physiological mechanisms that explain the end-exercise decrease in oxygen uptake [Formula: see text] during strenuous constant-power exercise, we recruited eleven trained, track cyclists. METHODS On two separated days they performed 1) resting spirometric measures, followed by an incremental test on a cycle ergometer to determine the power output at [Formula: see te...

Background: Inhaled bronchodilators can increase exercise capacity in chronic obstructive pulmonary disease (COPD) by reducing dynamic hyperinflation, but treatment is not always effective. This may reflect the degree to which the abdomen allows dynamic hyperinflation to occur. Method: A double blind, randomised, crossover trial of the effect of 5 mg nebulised salbutamol or saline on endurance ...

BACKGROUND Tiotropium partially relieves exertional dyspnea and reduces the risk of congestive heart failure in chronic obstructive pulmonary disease (COPD) patients. However, its effect on the sympathetic activation response to exercise is unknown. AIMS This study aimed to determine whether tiotropium use results in a sustained reduction in sympathetic activation during exercise. METHODS W...