Simple gel formulations may be applied to enhance the systemic and local exposure of potential compounds. The aim of this thesis is the development and characterization of controlled release formulations based on thermoreversible poloxamer gels, which are suitable for novel drug delivery applications. In particular co-solvents (DMSO, ethanol), mucoadhesive polymers (chitosan, alginate) and salt...

In this paper we analyze general Stackelberg games (SGs) and Stackelberg security games (SSGs). SGs are hierarchical adversarial games where players select actions or strategies to optimize their payoffs in a sequential manner. SSGs are a type of SGs that arise in security applications, where the strategies of the player that acts first consist in protecting subsets of targets and the strategie...

BACKGROUND Nutraceuticals help in combating some of the major health problems of the century including cancer, and 'nutraceutical formulations' have led to the new era of medicine and health. OBJECTIVE To develop different nutraceutical formulations and to assess the anticancer potential of nutraceutical formulations in N-methyl-N-nitrosourea (MNU)-induced mammary cancer in Sprague Dawley rat...

Key Points  Many novel analgesic formulations developed for human use are not practical or effective in veterinary patients  Available or pipeline novel analgesic formulations for veterinary patients are targeted towards extended delivery or ease of administration  Some novel analgesic formulations revolve around “old” analgesics (e.g. opioids) in a novel delivery matrix; however, while the ...