Dynamic treatment regimes are time-varying treatments that individualize sequences of treatments to the patient. The construction of dynamic treatment regimes is challenging because a patient will be eligible for some treatment components only if he has not responded (or has responded) to other treatment components. In addition there are usually a number of potentially useful treatment componen...

factorial and split-plot designs are two statistical procedures used to conduct agricultural field experiments. both designs are used frequently to quantify the main and interaction effects of two or more factors. however, split-plot design is recommended for specific situations depending on major and minor goals of the study, characteristics of the factors, and precision of statistical testing...