The level of phosphodiesterase (PDE) activity is lower in collagenase-isolated human fat cells than in adipose tissue fragments. The inhibition is not species-specific since collagenase also inhibits PDE in rat adipose tissue and bovine heart. In subcellular fractions from isolated fat cells, the PDE activities were lowest in the plasma membrane-enriched fractions and highest in the cytosolic f...

In this paper, we propose some recent works on data analysis and synthesis based on Empirical Mode Decomposition (EMD). Firstly, a direct 2D extension of original Huang EMD algorithm with application to texture analysis, and fractional Brownian motion synthesis. Secondly, an analytical version of EMD based on PDE in 1D-space is presented. We proposed an extension in 2D-case of the so-called “si...

The purpose of this work is the study of solution techniques for problems involving fractional powers of symmetric coercive elliptic operators in a bounded domain with Dirichlet boundary conditions. These operators can be realized as the Dirichlet to Neumann map for a degenerate/singular elliptic problem posed on a semi-infinite cylinder, which we analyze in the framework of weighted Sobolev sp...

This paper presents three new families of fractional Sobolev spaces and their accompanying theory in one dimension. The construction are based on a newly developed notion weak derivatives, which natural generalizations the well-established integer order theory. In particular, two one-sided introduced analyzed, they reveal more insights about another family so-called symmetric spaces. Many key t...

Motivated by applications to congested traffic problems, we establish higher integrability results for the gradient of local weak solutions strongly degenerate or singular elliptic PDE?div((|?u|?1)+q?1?u|?u|)=f,in?, where ? is a bounded domain in Rn n?2, 1<q<? and (?)+ stands positive part. We assume that datum f belongs suitable Sobolev Besov space. The main novelty here deal with case subquad...

We derive a partial integro differential equation (PIDE) which relates the price of a calendar spread to the prices of butterfly spreads and the functions describing the evolution of the process. These evolution functions are the forward local variance rate and a new concept called the forward local default arrival rate. We then specialize to the case where the only jump which can occur reduces...

Exposure of perfused rat lungs to lipopolysaccharides (LPS) causes induction of cyclooxygenase-2 followed by thromboxane (TX)-mediated bronchoconstriction (BC). Recently, phosphodiesterase (PDE) inhibitors have received much interest because they not only are bronchodilators but also can suppress release of proinflammatory mediators. In the present study, we investigated the effect of three dif...

The rod photoreceptor phosphodiesterase (PDE) is unique among all known vertebrate PDE families for several reasons. It is a catalytic heterodimer (alphabeta); it is directly activated by a G-protein, transducin; and its active sites are regulated by inhibitory gamma subunits. Rod PDE binds cGMP at two noncatalytic sites on the alphabeta dimer, but their function is unclear. We show that transd...

Recent studies have demonstrated that functionally discrete pools of phosphodiesterase (PDE) activity regulate distinct cellular functions. While the importance of localized pools of enzyme activity has become apparent, few studies have estimated enzyme activity within discrete subcellular compartments. Here we present an approach to estimate near-membrane PDE activity. First, total PDE activit...

The binding of cGMP to the noncatalytic sites on two isoforms of the phosphodiesterase (PDE) from mammalian rod outer segments has been characterized to evaluate their role in regulating PDE during phototransduction. Nonactivated, membrane-associated PDE (PDE-M, alpha beta gamma2) has one exchangeable site for cGMP binding; endogenous cGMP remains nonexchangeable at the second site. Non-activat...