Burc Molecular Genetik Tani ve Arastirma Laboratuvari Vali Konagi Cad. Orhan Ersek Sok. 19/2 34365 NisantasiŞişli, İstanbul, Turkey Tel: 902122919420, Fax: 902122472242 Aim: The aim was to investigate the interactions of hyperbaric oxygenation (HBO) and sulphur dioxide (SO2) inhalation (at 10 ppm, one hour daily for 45 days) on lipoperoxidation and fragility of RBC membranes. Methods: Malonyldi...

Osteoporosis has been named the silent disease because there are no symptoms until a fragility fracture occurs. With the rapid rise in the elderly population, the number of patients with osteoporosis and fragility fractures has increased in most developed countries. Fragility fractures increase societal burdens in terms of mortality and quality of life, as well as economic costs. Fragility frac...

Robustness, a long-recognized property of living systems, allows function in the face of uncertainty while fragility, i.e., extreme sensitivity, can potentially lead to catastrophic failure following seemingly innocuous perturbations. Carlson and Doyle hypothesized that highly-evolved networks, e.g., those involved in cell-cycle regulation, can be resistant to some perturbations while highly se...

The mitochondrial mass of rat brain and liver remained unchanged on aging in young adults, old adults, and senescent animals (28, 60, and 92 wk of age); the values were 15-17 and 29-31 mg protein/g for brain and liver, respectively. The whole aging process was associated with an increased content of the oxidation products, thiobarbituric acid-reactive substances and protein carbonyls, by 61-69%...

Chromosomal common fragile sites (CFSs) are unstable genomic regions that break under replication stress and are involved in structural variation. They frequently are sites of chromosomal rearrangements in cancer and of viral integration. However, CFSs are undercharacterized at the molecular level and thus difficult to predict computationally. Newly available genome-wide profiling studies provi...

The concept of seismic resilience needs a unified terminology and a common reference frame for quantitative evaluation. The evaluation can be based on nondimensional analytical functions related to variations of losses within a specified “recovery period”. The resilience must refer to both direct and indirect losses. The path to recovery usually depends on available resources and may take diffe...

Recent development of numerical modeling of tsunami and remote sensing technologies enable us to determine the detailed features of tsunami damage. Numerical model with high-accuracy and high-resolution bathymetry/topography grid predicts the local hydrodynamic features of tsunami, such as inundation depth and current velocity. Also, high-resolution satellite imagery provides detailed informati...

Inherited desmosomal diseases are characterised by skin and/or cardiac features. Dermatological features might be a clue in the determination of the underlying life-threatening cardiac disease. This article aims to propose a dermatological algorithm for the diagnosis of desmosomal diseases after a systematic review of published articles. Palmoplantar keratoderma (PPK), hair shaft anomalies and ...