OBJECTIVES To use multiple regression analysis to define the contribution of maternal variables that influence the measured concentration of free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A), and the interaction between these covariates, in first-trimester biochemical screening for trisomy 21. METHODS This was a multicenter study of prospecti...

OBJECTIVE To examine whether in pregnancies with fetal trisomy 21 the level of maternal serum free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) at 11 + 0 to 13 + 6 weeks' gestation is independent of the presence or absence of tricuspid regurgitation and to estimate the performance of a screening test that combines tricuspid regurgitation with f...

We describe a case of choriocarcinoma in which increased concentrations of beta-choriogonadotropin subunits in serum indicated recurrence of metastasis long before the tumor could be confirmed by visualization techniques, while intact choriogonadotropin remained normal (less than 5 int. units/L). Therefore, detection or monitoring of choriocarcinoma requires the assay of free beta-hCG subunit o...

Abstract Background The incidence of thyroid dysfunction in multiple sclerosis (MS) patients on interferon (as a disease-modifying line) has been reported many studies performed already therapy. Our study adopted prospective follow-up the profile those newly starting beta therapy over 1 year trying to find correlation between start and occurrence this dysfunction. Objectives To evaluate MS befo...

Effects of amyloid beta (Aβ) peptide Aβ(40) on secondary structures of Aβ(42) are studied by all-atom simulations using the GROMOS96 43a1 force field with explicit water. It is shown that in the presence of Aβ(40) the beta-content of monomer Aβ(42) is reduced. Since the fibril-prone conformation N∗ of full-length Aβ peptides has the shape of beta strand-loop-beta strand this result suggests tha...

We have established an estrogen receptor- and progesterone receptor-negative, hormone-nonresponsive breast cancer cell line from a receptor-positive, hormone-responsive line grown under estrogen-free conditions. T47D breast cancer cells were cultured under estrogenized conditions (in phenol red-containing medium supplemented with whole fetal bovine serum) and cloned to produce line T47D:A18. Th...

Pancreatic islets are responsible for blood glucose homeostasis. Reduced numbers of functional (insulin-secreting) beta-cells in pancreatic islets underlies diabetes. Restoration of the secretion of the proper amount of insulin is a goal. Beta-cell mass is increased by neogenesis, proliferation and cell hypertrophy, and is decreased by beta-cell death primarily through apoptosis. Many hormones ...

We report a case of postsurgical wound infection of polymicrobial etiology caused by Serratia marcescens and Pseudomonas aeruginosa following the use of a radial forearm free flap for oncological tongue reconstruction. S. marcescens was a producer of SHV-12 extended-spectrum beta-lactamase (ESBL). This is the first report from India of this ESBL. S. marcescens and P. aeruginosa were resistant t...

We investigate the localization transition for a simple model of interface which interacts with an inhomonegeous defect plane. The is modeled by graph function $\phi: \mathbb Z^2 \to Z$,and disorder given fixed realization field IID centered random variables$(\omega_x)_{x\in Z^2}$. Hamiltonian system depends on three parameters $\alpha,\beta>0$ and $h\in R$ determine respectively intensity near...

Capital Asset Pricing Model is widely used for estimating systematic risk in the form of Beta. Present study an attempt to estimate top 10 companies SENSEX, index Bombay Stock Exchange. For purpose monthly prices, converted simple return, selected and SENSEX 11 calendar years have been analysed. free return on 91 days Treasury Bills has considered. Results show that Beta 7 out considered, great...