i I, Introduction 1 II. Methods and Materials 2 III. Results and Discussion 5

n-acetyl cysteine (nac), as a nutritional supplement, is a greatly applied antioxidant in vivo and in vitro. nac is a precursor of l-cysteine that results in glutathione elevation biosynthesis. it acts directly as a scavenger of free radicals, especially oxygen radicals. nac is a powerful antioxidant. it is also recommended as a potential treatment option for different disorders resulted from g...

With a variety of forms of ischemic and toxic tissue injury, cellular accumulation of Ca2+ and generation of oxygen free radicals may have adverse effects upon cellular and, in particular, mitochondrial membranes. Damage to mitochondria, resulting in impaired ATP synthesis and diminished activity of cellular energy-dependent processes, could contribute to cell death. In order to model, in vitro...

Mahmoud Lotfy1 and Yousery E. Sherif2 1Associate Professor of Molecular Cell Biology & Immunology, Molecular and Cellular Biology Department, Genetic Engineering and Biotechnology Research Institute, Minufiya University, Sadat City, Minufiya, Egypt and Department of Applied Medical Sciences, Jouf University, Qurayat, 2Clinical Pharmacology Department, Faculty of Medicine, Mansoura University, M...

During the past several years, there has been a growing interest in the medical implications of free radicals. These chemical entities are common by-products of many oxidative biochemical reactions in the cell. Free radicals are essential to a number of normal biochemical and physiological processes. They are too reactive to be tolerated in living tissue, and aerobic organisms use sophisticated...

The possibility that cerebral ischemia may initiate a series of pathological free radical reactions within the membrane components of the CNS was investigated in the cat. The normally occurring electron transport radicals require adequate molecular oxygen for orderly transport of electrons and protons. A decrease in tissue oxygen removes the controls over the electron transport radicals, and al...

The 3D-partner is a web tool to predict interacting partners and binding models of a query protein sequence through structure complexes and a new scoring function. 3D-partner first utilizes IMPALA to identify homologous structures (templates) of a query from a heterodimer profile library. The interacting-partner sequence profiles of these templates are then used to search interacting candidates...

For the most part, the article in the Forum section titled "Free Radicals and Breast Cancer" [EHP 104:82 1 (1996)] accurately describes our paper "Progression of Human Breast Cancers to the Metastatic State Is Linked to Hydroxyl Radical-induced DNA Damage" (1). However, it was claimed that Some scientists have questioned the methodologies used by Malins and note that studies published in the Fe...