the use of methanesulfonic acid as a brønsted acid for direct ortho-acylation of phenols and naphthols proves to be a convenient, more general and direct route to various hydroxyaryl ketones. the route is regioselective, leading to ortho c-acylated products in satisfactory to high yields in most cases. the solvent free reactions described below exhibited environmentally benign in terms of faste...

Porous ionic polymers have demonstrated great potential for high-performance separation by the merits of their unique molecular recognition, but preparation anion-functionalized bioactive molecules with highly similar structures remains a challenge. Here, through facile Friedel-Crafts alkylation between benzylimidazole liquids (ILs) and crosslinkers, several hypercrosslinked porous (HIPs) are r...

We report the supramolecular assembly of artificial metalloenzymes (ArMs), based on Lactococcal multidrug resistance regulator (LmrR) and an exogeneous copper(II)–phenanthroline complex, in cytoplasm E. coli cells. A combination catalysis, cell-fractionation, inhibitor experiments, supplemented with in-cell solid-state NMR spectroscopy, confirmed assembly. The ArM-containing whole cells were ac...

Key words Prins reaction - Friedel–Crafts acylation piperidine schizophrenia

A-86929, a dopamine D1 agonist was synthesized with 95% ee in five steps with overall yield of 56% via catalytic enantioselective one-pot aziridination followed by Friedel-Crafts cyclization and a mild Pictet-Spengler cyclization protocol.

The catalytic activities of SBA-15 aluminosilica meso/macroporous monoliths (Si/Al = 72) and mesoporous powders (Si/Al = 70) have been investigated using batch Friedel–Crafts alkylation of single-ring aromatic compounds, including toluene, ethylbenzene, cumene, and styrene, with benzyl alcohol. The toluene alkylation activities of the meso/macroporous monolith catalysts were compared with nanop...