A link between excess dietary sugar and cardiac disease is clearly evident and has been largely attributed to systemic metabolic dysregulation. Now a new paradigm is emerging, and a compelling case can be made that fructose-associated heart injury may be attributed to the direct actions of fructose on cardiomyocytes. Plasma and cardiac fructose levels are elevated in patients with diabetes, and...

Although there are many well-documented metabolic effects linked to the fructose component of a very high sugar diet, a healthy diet is also likely to contain appreciable fructose, even if confined to that found in fruits and vegetables. These normal levels of fructose are metabolized in specialized pathways that synergize with glucose at several metabolic steps. Glucose potentiates fructose ab...

Glucose formed from [5-T]fructose in rat hepatocytes contains about 10 to 30% tritium. This does not appear to be due to fructose metabolism via hexokinase since neither the initial presence of glucose, nor wide variations in the original fructose concentration, have much effect on the relative labeling of glucose versus water from [5-T]fructose. Comparison of the T:14C ratios in glucose produc...

Widespread consumption of high-fructose and high-fat diets relates to the global epidemic of hypertension. Hypertension may originate from early life by a combination of prenatal and postnatal nutritional insults. We examined whether maternal high-fructose diet increases vulnerability to post-weaning high-fructose or high-fat diets induced hypertension in adult offspring and determined the unde...

OBJECTIVES The purpose of the present study was to ascertain whether pediatric patients with chronic abdominal pain had concurrent fructose intolerance as determined by a standardized dose breath hydrogen test (BHT), and whether symptoms would improve with a low-fructose diet. METHODS The fructose BHT test was administered to patients evaluated in clinic with unexplained chronic abdominal pai...

This review explores the effects of fructose on hippocampus: hippocampal function and structure, neurogenesis, cognitive function. First, this result confirms that excess intake affects microstructure pathways connecting hippocampus to other brain areas. Fructose has potential affect neurogenesis in hippocampus, a diet high can impair learning memory, leading impairment. However, further resear...

Pyrophosphate:fructose-6-phosphate phosphotransferase (PFP) was purified over 500-cold from endosperm of germinating castor bean (Ricinus commiunis L. var. Hale). The kinetic properties of the purified enzyme were studied. PFP was specific for pyrophosphate and had a requirement for a divalent metal ion. The pH optimum for activity was 7.3 to 7.7. The enzyme had similar activities in the forwar...

High-fructose intake in healthy men is associated with characteristics of metabolic syndrome. Extensive knowledge exists about the differences between hepatic fructose and glucose metabolism and fructose-specific mechanisms favoring the development of metabolic disturbances. Nevertheless, the causal relationship between fructose consumption and metabolic alterations is still debated. Multiple e...

The food industry has long known that "a spoonful of sugar helps the medicine go down in the most delightful way." And cane sugar had been America's most delightful sweetener of choice, that is, until the 1970s, when the much less expensive corn-derived sweeteners like maltodextrin and high-fructose corn syrup were developed. While regular table sugar (sucrose) is 50% fructose and 50% glucose, ...

Fructose does not maintain the electrical activity of the cerebral cortex in the hepatectomized animal (1). However, whole brain (2) and cortex (3) oxidize fructose in vitro. These facts may be explained by assuming that the brain cells are impermeable to fructose in viva, or that the oxidation of fructose is not concerned in the maintenance of cortical activity. The latter supposition makes it...