Penetrating injury to the head is considered a form of severe traumatic brain injury. Although uncommon, most neurosurgical centres would have experienced treating patients with such an injury. Despite the presence of well written guidelines for managing these cases, surgical treatment requires an individualized approach tailored to the situation at hand. We describe a collection of three cases...

conclusions anesthetic and surgical management was difficult due to the inability to position in supine and rapidly progressing hemorrhagic shock. surgical management for extraction of this iron bar and intensive monitoring and resuscitation resulted in an uneventful successful outcome. introduction penetrating thoracoabdominal injuries are potentially life threatening due to the associated hem...

Extensive shielding by N-glycans on the surface of the HIV envelope glycoproteins (Env) restricts B cell recognition of conserved neutralizing determinants. Elicitation of broadly neutralizing antibodies (bNAbs) in selected HIV-infected individuals reveals that Abs capable of penetrating the glycan shield can be generated by the B cell repertoire. Accordingly, we sought to determine if targeted...

A 41-year-old male presented with penetrating carotid artery injury after being stabbed in the left neck with a knife. He had profuse bleeding from the wound and was in hemorrhagic shock. No neuroimaging evaluation was possible, so emergent surgery was begun with continuous manual compression of the left neck. Graft reconstruction of the injured carotid artery was performed. He recovered well w...

An elite level fencer sustained a penetrating wound to the upper arm after his opponent's blade broke. Standard care for a deep puncture wound was given but it was some time before the athlete presented symptoms of a pneumothorax, which was confirmed by radiograph. Although resolution of this case was unremarkable, the possibility of penetrating thoracic injury, even when the point of entry is ...

Orbital penetrating injuries may cause significant harm to the optic nerves and eyeball as well as to the brain and cerebral vessels. Management of orbital foreign bodies should include prompt recognition of the extent of the injury, broad-spectrum parenteral antibiotics, tetanus prophylaxis, anticonvulsant medication and early surgical intervention under direct vision to remove the foreign bod...

Hepatic arterial injury secondary to both blunt and penetrating traumas is well documented in the literature by case reports and articles regarding management. Penetrating injuries to the hepatic arteries are more common than injuries from blunt trauma. Hepatic arterial injuries secondary to blunt traumas are often associated with injuries to other vital organs or vascular structures, resulting...

trauma continues to be the most frequent cause of death in the first four decades of life that is a main public health problem in some countries. we perform an epidemiological study of penetrating abdominal trauma (pat). we describe epidemiological of patients in pat. in a cross-sectional study we evaluated epidemiological pat admitted to emergency department in six general hospitals in tehran....

purpose: to report a case of recurrent keratoconus after penetrating keratoplasty (pk). patient and findings: a 31-year-old male patient who had undergone pk in his right eye for keratoconus 10 years ago presented with gradually decreased vision in the right eye. clinical, topographic, and histopathologic features of the cornea including irregular myopic astigmatism, central and paracentral cor...

Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This r...